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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Yohanes Firmansyah
Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation between Facial Skin Damage Due to UV Exposure and Facial Skin Porphyrin Level: Study on Students of SMA Kalam Kudus II Jakarta, Indonesia Fendy Wellen; Sukmawati Tansil Tan; Yohanes Firmansyah; Hendsun Hendsun
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.737

Abstract

Background: UV exposure causes physical and chemical damage. UV causes damage to the skin barrier physically due to the heating process. Meanwhile, chemically, UV causes the formation of oxidants which are responsible for the process of oxidative stress. Damage to skin cells causes loss of the body's natural barrier against various threats from microorganisms. Propionibacterium acnes is one of the commensal bacteria on the skin, which will produce products in the form of porphyrins. This study aimed to determine the correlation between UV-induced skin damage and porphyrin levels in SMA Kalam Kudus II Jakarta, Indonesia. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 92 research subjects who were students of SMA Kalam Kudus II Jakarta, Indonesia, participated in this study. Facial skin porphyrin levels and levels of facial skin damage due to sun exposure (UV damage proportion) as measured by a skin analyzer. UV damage and porphyrin assessments according to the T Zone and V Zone regions and obtained the average results from the 3 regions. Correlation analysis was performed with the help of SPSS software. Results: The higher the percentage of skin damage due to UV correlated positively with the higher the percentage of porphyrin levels, with a value of r = 0.529. Conclusion: There is a positive correlation between UV-induced skin damage and porphyrin levels in students of SMA Kalam Kudus II Jakarta, Indonesia.
Correlation between Facial Skin Damage Due to UV Exposure and Facial Skin Porphyrin Level: Study on Students of SMA Kalam Kudus II Jakarta, Indonesia Fendy Wellen; Sukmawati Tansil Tan; Yohanes Firmansyah; Hendsun Hendsun
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.737

Abstract

Background: UV exposure causes physical and chemical damage. UV causes damage to the skin barrier physically due to the heating process. Meanwhile, chemically, UV causes the formation of oxidants which are responsible for the process of oxidative stress. Damage to skin cells causes loss of the body's natural barrier against various threats from microorganisms. Propionibacterium acnes is one of the commensal bacteria on the skin, which will produce products in the form of porphyrins. This study aimed to determine the correlation between UV-induced skin damage and porphyrin levels in SMA Kalam Kudus II Jakarta, Indonesia. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 92 research subjects who were students of SMA Kalam Kudus II Jakarta, Indonesia, participated in this study. Facial skin porphyrin levels and levels of facial skin damage due to sun exposure (UV damage proportion) as measured by a skin analyzer. UV damage and porphyrin assessments according to the T Zone and V Zone regions and obtained the average results from the 3 regions. Correlation analysis was performed with the help of SPSS software. Results: The higher the percentage of skin damage due to UV correlated positively with the higher the percentage of porphyrin levels, with a value of r = 0.529. Conclusion: There is a positive correlation between UV-induced skin damage and porphyrin levels in students of SMA Kalam Kudus II Jakarta, Indonesia.
The Effectiveness of Combination Therapy of Needling and Secretome from Mesenchymal Stem Cells (Serum 10%) for Acne Scar Treatment Sukmawati Tansil Tan; Yohanes Firmansyah; William Gilbert Satyanegara; Edwin Destra; Giovanno Sebastian Yogie; Catharina Sagita Moniaga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.832

Abstract

Background: Acne scars can have various impacts on individuals, both physical and psychological. Acne scars arise as a result of complications from acne vulgaris. This study purposed to determine the effectiveness of the treatment using a combination of SC-PWJMSC with microneedling for acne scars. Methods: Pre-post clinical trial involving patients with acne scar. The intervention used in this study was a combination therapy of microneedling and secretome from mesenchymal stem cells. The intervention was carried out 1 time and monitored for 42 days. Primary outcome in the form of Observer visual scar assessment scale (OVSAS) was assessed at baseline and 42nd day, Secondary outcome (regenerative parameters) was assessed at baseline, 21st day and 42nd day. Results: There was a significant change in the primary and secondary outcomes (p-value <0.001) without any significant side effects. Conclusion: This study showed that combining needing with secretome from mesenchymal stem cells (MSCs) led to satisfactory results in repairing acne scars and in a number of other ways (secondary outcomes). On the other hand, there are limitations in this study in the form of no comparison therapy for the treatment of acne scar.
The Effectiveness of Combination Therapy of Needling and Secretome from Mesenchymal Stem Cells (Serum 10%) for Acne Scar Treatment Sukmawati Tansil Tan; Yohanes Firmansyah; William Gilbert Satyanegara; Edwin Destra; Giovanno Sebastian Yogie; Catharina Sagita Moniaga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.832

Abstract

Background: Acne scars can have various impacts on individuals, both physical and psychological. Acne scars arise as a result of complications from acne vulgaris. This study purposed to determine the effectiveness of the treatment using a combination of SC-PWJMSC with microneedling for acne scars. Methods: Pre-post clinical trial involving patients with acne scar. The intervention used in this study was a combination therapy of microneedling and secretome from mesenchymal stem cells. The intervention was carried out 1 time and monitored for 42 days. Primary outcome in the form of Observer visual scar assessment scale (OVSAS) was assessed at baseline and 42nd day, Secondary outcome (regenerative parameters) was assessed at baseline, 21st day and 42nd day. Results: There was a significant change in the primary and secondary outcomes (p-value <0.001) without any significant side effects. Conclusion: This study showed that combining needing with secretome from mesenchymal stem cells (MSCs) led to satisfactory results in repairing acne scars and in a number of other ways (secondary outcomes). On the other hand, there are limitations in this study in the form of no comparison therapy for the treatment of acne scar.
Co-Authors Catharina Sagita Moniaga Edwin Destra Fendy Wellen Giovanno Sebastian Yogie Hendsun Hendsun Sukmawati Tansil Tan Sukmawati Tansil Tan William Gilbert Satyanegara