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All Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR)
Artrien Adhiputri
Departement Of Pulmonology And Respiratory Medicine, Medical Faculty, Universitas Sebelas Maret, Surakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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The Degree of Inflammation and Length of Hospital Stay in Acute Exacerbation of COPD Patients After Secretome Administration Hendrastutik Apriningsih; Yusup Subagio Sutanto; Reviono Reviono; Artrien Adhiputri; Windu Prasetya; Fahlevie Fahlevie; Fitrotin Aziza
Jurnal Respirologi Indonesia Vol 43, No 1 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i1.390

Abstract

Background: Acute exacerbation of COPD (AECOPD) is a decrease in respiratory conditions compared with regular conditions that require additional treatment, increase risk of hospitalization or demand intensive care unit. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system and is considered as an important systemic inflammatory marker. Length of hospital stay (LHS) is important in predicting the severity of AECOPD, in which longer LHS indicates greater severity of AECOPD. Secretome has been shown to have the ability to exert immunomodulatory effects, reduce lung injury and inflammation in several models of lung inflammation and immune-mediated lung disease. This study aimed to assess the differences between NLR and LHS in AECOPD patients who received a secretome and those who did not.Methods: This study involved 30 AECOPD patients whom assigned into two groups. Secretome and standard therapy were administered in the treatment group, whilst the control group only received the standard therapy. Statistical analysis used different test, the unpaired group difference test using Mann Whitney and the independent test, the paired group difference test using Wilcoxon rank test and Pair test. Result is significant if the P<0.05.Results: NLR value in the treatment group experienced a lower increase than the control group, yet statistically insignificant (P=0,187). Secretome decreased the LHS in AECOPD patients, and statistically significant with (P=0,028). Conclusion: Administration of secretome led to a lower increase in NLR value and decreased LHS AECOPD patients.
Interleukin-6 and Neutrophil–Lymphocyte Ratio in Predicting Outcome of Confirmed COVID-19 Patients Harsini Harsini; Jatu Aphridasari; Artrien Adhiputri; Agung Prasetyo; Hie Sukiyanto; Aditya Sri Listyoko
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.108-116

Abstract

Introduction: COVID-19 emerged as a pandemic about 2 years ago. Severe and critical COVID-19 has been associated with increased interleukin 6 (IL-6) level and neutrophil–lymphocyte ratio (NLR). This study aimed to test whether IL-6 and/or NLR are associated with COVID-19 mortality. Methods: Subjects were COVID-19 patients with suspected Omicron variant infection that were hospitalized at Dr. Moewardi Hospital from October 2021 to March 2022. According to their medical records, subjects were divided into survivor and non-survivor groups. Serum level of IL-6 and NLR at admission were recorded, compared, and analyzed for association with mortality. Results: Seventy-four respondents, average age 53.07 ± 16.2 years, joined the research. The area under curve (AUC) value of IL-6 was 0.740, with a cut-off value of 42.00 mg/dL (73.9% sensitivity; 70.6% specificity). The AUC value of NLR was 0.721, with a cut-off value of 5.51 (73.9% sensitivity; 60.8% specificity). IL-6 had a higher odds ratio than NLR as a risk factor for mortality (6.80 [95% CI 2.24–20.61; p < 0.001]; 4.39 [95% CI 1.48–13.03; p < 0.001], respectively). The correlation between IL-6 and NLR had an r-value of 0.164 (p = 0.164). Conclusion: There was no difference in sensitivity between IL-6 level and NLR as mortality predictors of COVID-19, but serum IL-6 level was more specific. IL-6 level correlated positively with NLR, but there was no significance.
Co-Authors Aditya Sri Listyoko Agung Prasetyo Aphridasari, Jatu Fahlevie Fahlevie Fitrotin Aziza Harsini Hendrastutik Apriningsih Hie Sukiyanto Reviono Reviono Windu Prasetya Yusup Subagio Sutanto