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Yasser Fakri Mustafa
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Medicine & Pharmacology

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Synthesis, Antioxidant, and Preliminary Antitumor Activities of New Curcumin Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Curcumin is a molecule gifted from nature to improve human health by its multiple biological activities. However, the application of curcumin in therapeutics is limited mainly due to its poor aqueous solubility, insignificant chemical stability, and low cellular uptake. To address some of these drawbacks, eight analogues of curcumin were synthesized starting from simple molecules. Characterization of the chemical structures of these analogues was documented by interpretation of their IR, 1H-NMR, and 13C-NMR spectra. Biological activities of the synthesized analogues were studied by comparing their activities with those of curcumin. This biological assessment included examining the antioxidant capacity via DPPH and hydroxyl radical scavenging activity tests, and screening the preliminary antitumor activity against MCF-7 and HeLa cancer cell lines by MTT test. Depending on the resulted data, it was found that these analogues have the comparable biological activities but with better stability and water solubility in comparison with curcumin. It is postulated that such analogues may be useful clues to improve the therapeutic applications of curcumin.Keywords: Curcumin, Synthesis, Analogues, Antioxidant, Antitumor.
Synthesis, Characterization and Preliminary Cytotoxic Study of Sinapic Acid and its Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The use of natural products to treat human diseases especially cancer is an interesting trend in pharmaceutical research. Sinapic acid, being a member of hydroxycinnamic acid family and having well-established pharmacological properties, could have a potential antitumor activity that has not been investigated sufficiently. This work aimed to test the preliminary cytotoxic effect of sinapic acid and nine of its synthesized analogues utilizing MTT assay on four cancer cell lines; which are: HeLa, AMN3, SKG, and MCF-7. The chemical structures of the intermediates and of the synthesized products were approving by analyzing their IR, 1H-NMR, 13C-NMR, and MS-ESI spectra. Results of the cytotoxicity study indicated that sinapic acid analogues 3a, 3c, 3d, 3e and 3h have lower IC50 values  than that of positive control on the tested cancer cell lines, while sinapic acid itself and the other synthesized analogues did not have such cytotoxic effect.Keywords: Sinapic acid, Analogues, Gastrodigenin, MTT, Cytotoxicity.
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