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Giri Chandra
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Medicine & Pharmacology

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Apoptotic Index of Amniotic Membrane Cells in Preterm Labor with Premature Rupture of Membrane (PPROM) was Higher than Preterm Labor without Premature Rupture of Membrane Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Premature rupture of the membrane in preterm pregnancy is a condition that can cause increased maternal and perinatal morbidity and mortality. The study aims to compare the apoptotic index of amniotic membrane cells in preterm labor with premature rupture of membrane (PPROM) and without premature rupture of membrane. Method: This is a cross sectional study conducted at the Department of Obstetrics and Gynecology, Sanglah Hospital Bali. The Amniotic membranes were taken from the placenta after delivery then apoptotic index was measured by TUNEL examination. Result: The study included each 20 women from both groups. There was no significant difference of maternal age, gestational age, and BMI between groups (p>0,05). Chi-square analysis showed there was an association between the apoptotic index and preterm labor with PROM (p = 0.001). Subsequent analysis resulted in prevalence ratio of 19.0 (95% CI = 2.81 - 128.6). Conclusion: This study concluded that the apoptotic index of amniotic membrane cells in PPROM was higher than preterm labor without premature rupture of membrane. Keywords: Apoptotic index, Preterm Premature Rupture of Membrane, PPROM.
The Characteristic of Congenital Fetal Anomalies at Sanglah Birth Defect Integrated Center (SIDIC), Sanglah General Hospital, Bali Indonesia Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction. Congenital anomalies are among the cause of neonatal morbidity and mortality. The aim of this study was to measure the occurrence of congenital fetal anomalies and explored the distribution of specific anomaly at SIDIC (Sanglah Birth Defect Integrated Center), Sanglah General Hospital Bali, Indonesia. Method. The study was a descriptive study of congenital anomalies who were screened at Maternal-Fetal Medicine Division outpatient clinic and who were delivered at Sanglah General Hospital Bali, Indonesia during the period January 2017-December 2018. Result. During two years study period, there were 109 pregnant women who gave birth to 118 babies with congenital anomalies. The system most involved were Gastrointestinal System 21.2% and Central Nervous System 21.2%. The majority of mother (70.6%) was at 20-35 years old. Regarding the gestational age, the majority accounting for 38.5% were at 28 - 34 weeks. Conclusion. In this descriptive study, the incidence of congenital anomalies most involving gastrointestinal system and Central Nervous system. Advanced in the knowledge of congenital anomalies could be important for better prevention. The preventive strategies such as preconception counselling, focused antenatal care, and care to optimized women’s health should be implemented. Keywords: Congenital anomalies, SIDIC, Fetal anomalies.
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