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All Journal eJournal Kedokteran Indonesia Journal of Global Pharma Technology
Riyadh Firdaus
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) as proinflammatory cytokines in traumatic brain injury (TBI) of rat (Sprague-Dawley) : A study of propofol administration Riyadh Firdaus; Franciscus Dhyana Giri Suyatna; Aida Rosita Tantri; Yetty Ramli; Ekowati Handharyani; Arni Diana Fitri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.843 KB)

Abstract

The increase in the prevalence of traumatic brain injury (TBI) followed by increased morbidity and mortality challenges anesthetists to perform the treatment patients with TBI. Menwhile, interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) are the first pro-inflammatory markers expressed after secondary injury occurs. In addition, propofol (2,6-disopropylphenol) is a short-acting intravenous agent that reported to play role in inflammatory process. This study aims to determine the effects of propofol administration on the neuroinflammatory pathway. Thirty adult female Sprague Dawley rats were randomly assigned as TBI rats (T), rats that received propofol infusion (P), or TBI rats that received propofol infusion (TP). The rat model of TBI was developed using the Marmarou Weight Drop method. Clinical assessment was performed using the Neurobehavioral Severity Score-Revised (NSS-R). Brain tissues were taken 24 h after TBI and the levels of interleukin-1 (IL-1) and interleukin-6 (IL-6) mRNA expression levels were examined using qRT-PCR, while the concentration were examined using ELISA and immunohistochemistry. On clinical examination, a decrease in the median value of NSS-R in the TP group was found from 30th minute to 120th minute. 24 hours after the occurrence of TBI, there was a decrease in both the TP and T groups. However, the NSS-R values in the TP group were lower than those in the T group. The expression of IL-1β was found in the nuclei and cytosol, while IL-6 was found in the axons and cytosol. The expression and concentration of IL-1β and IL-6 were the highest in the TP group, followed by the P and then the T group. Propofol can improve neurological function in rats with TBI, probably through the mechanism involves neuroinflammatory pathways, particularly IL-1β and IL-6.
Blok Erector Spinae Plane (ESP) pada Operasi Tulang Belakang Lumbal: Laporan Kasus Berbasis Bukti Annisaa Yuneva; Maria Y. Tita; Hana F. Herianti; Andy Omega; Riyadh Firdaus
eJournal Kedokteran Indonesia Vol 11, No. 1 - April 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.229.59-67

Abstract

Pada pasien yang menjalani operasi tulang belakang area lumbal, nyeri pasca operasi merupakan salah satu yang menyebabkan tingginya kebutuhan opioid, memperpanjang durasi lama rawat, dan ketidakpuasan pada pasien. Tujuan penelitian ini adalah. menentukan efektivitas blok erector spinae plane (ESP) pada operasi tulang belakang area lumbal berdasarkan langkah-langkah Evidence-based Medicine (EBM). Pencarian literatur dilakukan sesuai pertanyaan klinis dan terstruktur menggunakan PubMed, Cochrane Library, dan ProQuest. Pada artikel yang terpilih kemudian dilakukan telaah kritis terhadap kesahihan (validity), pentingnya hasil (importance), dan kemamputerapan (applicability) pada hasil. Setelah proses seleksi sesuai kriteria inklusi dan eksklusi didapatkan satu artikel yang sesuai dengan tujuan laporan ini, berupa 5 RCT dan 2 tinjauan sistematis. Luaran dari studi ini melingkupi nyeri pasca operasi, kebutuhan analgesi tambahan, insidensi post-operative nausea and vomiting (PONV), kepuasan pasien, dan komplikasi blok ESP. Disimpulkan, blok ESP efektif dalam memberikan analgesi intraoperatif dan pasca operasi pada pasien yang menjalani operasi tulang belakang area lumbal, dengan prosedur yang relatif aman dan komplikasi minimal.
Co-Authors Andy Omega Annisaa Yuneva Arni Diana Fitri Ekowati Handharyani Franciscus Dhyana Giri Suyatna Hana F. Herianti Maria Y. Tita Tantri, Aida Rosita Yetty Ramli