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Lina Saadi
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Medicine & Pharmacology

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Synthesis and Characterization of (Five, Six) Hetrocycyclic Derivatives from Imidazole and Studying of their Biological Activity Lina Saadi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract

This research involve synthesis (Pyrazol,isoxazole ,Oxazine, Thiazine, Pyridine, pyrimidine) derivatives by three different steps, The first step includes coupling reaction between 3-amino acetophenonediazonium chloride with imidazole in alkaline alcoholic solution to form (1-(3-((1H-imidazol-2-yl)diazenyl)phenyl)ethan-1-one) (1) ,while second step includes reaction(1) with (3,4-Dimethoxy benzaldehyde) to get chalcone derivative (2),while the third step includes reaction(2) with (hydrazine ,phenyl hydrazine ,2,4 dinitrophenyl hydrazine, hydroxylamine hydrochlorid, urea, tiourea, ethyl cyanoacetate, malononitrile, guanidine hydrochloride) to get (five and six ) hetrocyclicderivatives, heterocyclic compounds have been characterized by FT-IR, 1H-NMR and13C-NMR  analysis and study the biological activity for all derivatives to word two types of becteria.Keywords:  Azo, pyrazole, chalcone ,oxazine, thiazine,  pyridine, pyrimidine.                                                                                    
Synthesis and Characterization of Some Heterocyclic Compounds from Chalcone Derivatives and Studying of their Biological Activity Lina Saadi
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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In this work a preliminary step was preparation of 1-(3-((1H-imidazol-2-yl)diazenyl)phenyl)ethan-1-one (1) via coupling of diazonium salt of m-amino acetophenone with imidazole in alkaline alcoholic media which is followed to condensation with different aromatic aldehydes (p-tolualdehyde ,4-dimethyl amino benzaldehyde ) by aldol condensation in the presence of base in ethanol to give chalcones derivatives (2,3), that consider as excellent starting material for synthesis of many heterocyclic derivatives through its reaction with (hydrazine ,phenyl hydrazine ,2,4 dinitrophenyl hydrazine) to get pyrazol derivatives (4-9), likewise (2,3) react with hydroxylamine hydrochloride to get isoxazole (10,11), also (2,3) react with (urea, tiourea) to get oxazine and thiazine derivatives (12-15) , as well (2,3) react with (ethyl cyanoacetate, malononitrile) to get pyridine derivatives (16-19) ,too (2,3) react with guanidine hydrochloride to get pyrimidine derivatives (20,21). All these compounds characterized by means of FT- IR, 1H-NMR, and 13C-NMR, and follow reaction by Rf- TLC and measurements melting points. After that we studied the biological activity for all prepared compounds to ward two types of bacteria.Keywords: Azo, Chalcone, Pyrazole, Isoxzazole , Oxazine, Thiazine,  Pyridine , Pyrimidine, Biological activity.
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