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S. Sivakrishnan
Annamalai university
Medicine & Pharmacology

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Isolation of active compounds from aerial parts of Albizia Procera S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The purpose of the study is to isolate active compounds from herbal plants that have various effects on living systems. The plants are indispensable sources for both preventive and curative medicinal preparations of various traditional medicine systems practiced worldwide. Albizia species is used to treat anxiety, cancer, depression, insomnia, sore throat and to reduce swelling associated with trauma. Isolation of active constituents and pharmacological screening can assist us to find new therapeutically active drugs. The compound (1) 2,2- dimethylvinyl methyl ketone and  compound (2) 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene (C30H50) are isolated from hexane and ethyl acetate fraction of albizia procera belonging to the family mimosoideae. The above isolated Compound (1) is an intermediate to synthesis a number of different types of organic compounds and Compound (2) showed potential hepatoprotective effect against drug induced hepatotoxicity. The structure of compound have been established [1] by IR, 1H NMR, 13C NMR and MASS spectrophotometry.
Antioxidant Potential, Total Phenolic and Flavonoids Content of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Objective: The aim of this work was to estimate the total phenolic and flavonoids content, and to evaluate in-vitro antioxidant activity of ethanolic extract of Cordia obliqua.Methods: The ethanolic extract of Cordia obliqua was examined by Iron chelating activity, Total antioxidant activity, Total phenol and flavonoids with reference standard EDTA (Ethylenediaminetetraacetic acid), Ascorbate and catechol respectively through in vitro models.Results: The antioxidant activities of the extract were positively associated with the total phenolic and flavonoid contents of the ethanolic extract of cordia obliqua.Conclusion: Ethanolic extract of Cordia obliqua. showed strong scavenging activity. These in vitro assays indicate that this plant extract is a better source of natural antioxidants. The presence of antioxidants such as phenolics, flavonoids, tannins and proanthocyanidins in plants may provide protection against a number of diseases including cancer, neurodegeneration and inflammation. 
Frap Assay and Nitric Oxide Free Radical Scavenging Activity of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Objective: Oxidative stress resulting from accumulation of reactive oxygen species has been associated with disease. Research study was undertaken to investigate and evaluate the in vitro antioxidant activities such as FRAP and Nitric oxide of ethanolic extract of cordia obliqua.Methods: The ethanolic extract of cordia obliqua was examined by Nitric oxide radical scavenging activity and Ferric Reducing Antioxidant Power Assay with reference standard ascorbate respectively through in vitro models.Results: Ethanolic extract of cordia obliqua showed significant free radical scavenging activity than that of standard.Conclusion: In vitro study indicates that these plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.
Herbal Drugs, Diet and Lifestyle Changes for Liver Diseases- A Review S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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The liver is an important part of human digestive system. The organ’s function include food metabolism, energy storage, waste removal, detoxicification, immune system support and production of chemicals. There are several things damage the liver such as toxic substances, viruses, medications, genetic diseases and alcohol. Some of the herbal drugs and its extracts showed a good potentials for use in liver diseases.  Therefore, the present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity. In addition diet and lifestyle changes can help to improve the conditions of hepatotoxicity. 
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