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Ali Hussein Al-Marzoqi
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Medicine & Pharmacology

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Incidence of EBV and HTLV-1 Infection Associated With Leukemia Patients Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

Multidrug insurance (MDR) in hurt cells is a phenotype whereby cells show decreased affectability to anticancer arrangements, in setting of a blend of instruments, joining a development in persevering efflux, the diminishment of pharmaceutical take-up, the incitation of cell change and survival hailing, the advance of DNA repair, and the impediment of apoptosis hailing. Widened verbalization of the plasma layer quiet efflux pumps, the ATP-confining tape (ABC) transporters, is associated with MDR. P-Glycoprotein/ABCB1 is a man from the ABC transporter family, and animates the efflux of various anticancer meds, including anthracyclines, vinca alkaloids, epipodophyllotoxins, taxanes, and kinase inhibitors, from cells. Infections by herpesviruses are enduring considers in patients being supervised for wearisome leukemia and those encountering bone marrow transplantation. Reactivation of endogenous sit without moving sullying caused by the immunosuppressive and cytotoxic effects of cytoreductive pharmaceuticals is a normal instrument of infection. With HTLV-1 securing of exogenous contamination by transfusion of blood things containing sickness and from the bone marrow join by restraint of bone marrow transplantation can happen.Keywords: Human T-lymphotropic Virus; Herpesvirus; ABC; MDR.
Genetic Study for the Role and Predictive Consequence of Certain Cytokines in Hepatitis B Iraqi Patients Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Hepatitis B virus (HBV) infection is a serious and common infectious disease of the liver, HBV infection is endemic, particularly in developing countries, and is a serious public health problem. Cytokines and regulatory molecules play a fundamental role in the immuno pathogenesis of HBV infection. The gene loci for cytokines are defined, and polymorphisms of these genes are suggested to influence the outcome of HBV infection. In our study we revealed that there are elevated in Aspartate transaminase (AST), Alanine transaminase (ALT) and Bilirubin (Bil) among HBV patient than control group. IL–4 rs2070874 SNP Genotypes among patients with HBV was ONLY 68 positive to PCR results while in contrast it is only 9 within control group. The highest ratio of genotype in both groups was in CC as 36 (52.9%) in patients and 5 (55.6%) in control. Allele frequency on other hands describe as follow;  in HBV and control group for C 72 (63.7%), 11 (61.1%) while for T 41 (26.3%) and 7 (38.9%) respectively. Genotypes of IL–10 rs1800872SNP among patients was in AA as 43 (62.3%) in patients and 13 (76.5%) in control. On other hands Allele frequency describe as follow; in HBV and control group for A 106 (76.8%), 29 (85.3%) while for G 32 (23.2%) and 5 (14.7%). IFN-γ (rs2069705 SNP) Genotypes among patients with HBV was in AG as 39 (28.8%) in patients and 10 (47.6%) in control with GG. Allele frequency. Moreover, describe as follow; in HBV and control group for A 61 (33.3%), 28 (66.7%) while for G 122 (66.7%) and 28 (66.7%)Keywords: Hepatitis, Cytokines, PCR, IFN, SNPs, IL-10, IL-2.
Antimicrobial Effect of the Crude Phenolic, Alkaloid and Terpenoid Compounds Extracts of Myrtus Communis L. against Human Gram-Negative Pathogenic Bacteria Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Objective: To reveal the effect of the crude phenol, alkaloid and torpedoed compounds extracts of Mitres Communes L. on some Human gram-negative Pathogenic Bacteria. Methods Antibacterial activities of the crude Phenol, Alkaloid and Torpedoed of medicinal plant were determined in vitro by agar well diffusion-method against some human pathogenic bacteria. Results obtained results showed that active compounds of Mitres Communes L. had wide spectrum antibacterial activity against gram- gram-negative bacteria Conclusion This study demonstrates that we can conclude that the effect of active compounds in same plant has different effect on different pathogenic organisms in different concentrations.Keywords: Antimicrobial, Myrtus Communis, L Pathogenic Bacteria, Gram-negative Bacteria.
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