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All Journal Journal of Global Pharma Technology Natural: Jurnal Pelaksanaan Pengabdian Bergerak Bersama Masyarakat
Zeyad Kadhim Oleiwi
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Synthesis and Characterization of Some New D-mannose Derivatives Containing 1, 2, 3-Triazole Moiety and Screening Their Action as Urease Inhibitors Zeyad Kadhim Oleiwi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.689 KB)

Abstract

Williamson etherification of (1) with propargyl bromide afforded the 1-O-propargyl-2, 3:5, 6-Di-O-isopropyli-dene α-D-mannofuranoside (2) in a very good yield. 1, 3-Dipolar cycloaddition of (2) with four different aryl azides derivatives using click conditions gave four new 1, 2, 3-triazole derivatives containing sugar moiety. The biological activity of synthesized compounds were tested against urease activity by immobilize this enzyme on the synthesized compounds. All of these compounds show inhibition activity of enzyme. Some of these compounds (T1) show high inhibition action on the enzyme activity, while (T2, T3, T4) show moderate effect on the activity.Keywords: Mannose, Derivatives, 1, 2, 3-triazole, Urease, Inhibitors.
Investigating the Effect of Thalassemia on Serum Creatinine, Uric Acid, and Cholesterol Levels Isam Mohammed turki; Intisar Obaid Alfatlawi; Zeyad kadhim Oleiwi
Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat. Vol. 2 No. 3 (2024): August : Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/natural.v2i3.563

Abstract

A thalassemia is a group of inherited blood disorders characterized by decreased or absent production of hemoglobin. Symptoms of thalassemia vary greatly from patient to patient but may include anemia, fatigue, and susceptibility to infections that can plague their quality of life. Therefore, a detailed evaluation of the serum biomarker profile in thalassemia patients is necessary to elucidate its effects on the body. This study was performed to define the serum biomarker profile. This study aimed to evaluate the serum marker levels among 100 thalassemic patients and compare them with their physiological ranges. Blood urea (B.UREA), serum creatinine (S.CREAT), aspartate aminotransferase (AST), alanine aminotransferase (Alt), alkaline phosphatase (ALP), total serum bilirubin (TSB), serum uric acid (S.U.A), triglycerides (TG), cholesterol (CHOL), albumin (Alb), serum calcium (S.CA) and Carbohydrate Antigen 15-3 (CA15.3) were analyzed comprehensively as key indicators in this study. The test showed that B. UREA's mean number was 24.33±0.8805, which was safe within normal limits. So, no abnormal results were found for this indicator in our tests despite the fact that others showed irregularity. The means of the values measured by S.CREAT, AST, AlT, AlP, TSB, S.U.A, TG, CHOL, AlB, S.CA, and CA15.3 were respectively, 0.8109±0.2007, 28.93±3.325, 26.1±2.698, 101±13.64, 3.261±1.978, 12.78±8.951, 146.8±87.2, 147.5±22.89, 67.94±44.7. This study makes valuable contributions to the field by elucidating the serum biomarkers of individuals with thalassemia and presenting changes in some markers compared to normal levels. However, further research is required in order to investigate the clinical significance of such alterations.2, 9.392±0.4079, and 42.08±7.275.
Co-Authors Intisar Obaid Alfatlawi Isam Mohammed turki