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Salwa R. Abdul-Ameer
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Medicine & Pharmacology

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Synthesis and Characterization of Some New Derivatives of 8-Chlorothiophyllìne by Microwave-Assist Suzuki-Miyaura Coupling Reaction Salwa R. Abdul-Ameer
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Some new derivatives of 8-Chlorothiophyllìne (8-CTh) synthesized by Suzuki reactions when react 8-CTh with hydrazine to give 8-hydrazinyl thiophyllìne. This compound reacts with 4-bromo benzaldehyde to give imine compound. The microwave-promoted Suzuki-Miyaura coupling of the latter compound with different aryl boronìc acids gave (3-9) compounds with good to excellent yields. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, and FT‐IR, 1H, 13C-NMR and 2D-NMR spectroscopy. The antibacterial action of these derivatives was also determined.Keywords: 8-Chlorothiophyllìne, Suzuki reaction, Microwave, Antibacterial, Antifungal.
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