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Alyaa Majid
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Medicine & Pharmacology

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Cardioprotective Activity of Polyphenolic Extract of Tubers of Cyperus Rotundus and Taurine against Isoproterenol - induced Myocardial Infraction in Rats: Troponin-I and Histological Findings Alyaa Majid
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Objective: The polyphenolic extract of tuberus of cyperus rotundus and taurine was studied for the cardio protective activity using isoproterenol induced myocardial infraction in female rats. Materials and Methods: Sixty of female rats (Rattus norvegicus) were used in the present study. Animals were divided into 10 groups ( 6 for each group). MI was induced in rats with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced significant alterations in the troponin-I and necrosis in the heart. The effect of polyphenolic extract of tuberus of cyperus rotundus oral treatment for 21 days at two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses (100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced cardiac necrosis. Results: Significant myocardial necrosis and increase in serum levels of troponin-I were observed in ISO- treated animals as compared with the normal control animals. Polyphenolic extract of tubers of cyperus rotundus and taurine showed a significant cardio protective activity by lowering the levels of serum troponin-I and less myocardial necrosis. Conclusion: These findings the synergistic cardio protective effects of polyphenolic extract of tubers of cyperus rotundus and taurine during ISO-induced myocardial infraction in rats.Keywords: Isoproterenol, Cardiac troponin I, Myocardial necrosis, Histology, Cyperus rotundus, Taurine.
Biochemical Study in Rats Hepatotoxicity with Carbon Tetrachloride and Treated with Camel Milk Alyaa Majid
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Objective: Carbon tetrachloride (CCl4) is a highly toxic chemical agent. Therefore, the present study was carried out to investigate the protective effects of camel's milk against CCL4 induced toxicity in male rats. Materials and methods:  Albino male rats (150-200 g) were divided into four groups of 6 rats: a control group fed only with diet and tap water for two weeks, the second group fed with standard diet and camel milk, the third group intoxicated with CCl4 on first two days of the experimental 14 days and fed with tap water and diet, and the fourth group intoxicated with CCl4 on first two days of the experimental 14 days and then treated with camel milk. Results: The results indicated that the CCl4 caused a significant increased in the level of  serum total cholesterol(TC) , triglycerides(TG), very low density lipoprotein (VLDL)and low density lipoprotein(LDL), lactate dehydrogenase(LDH), creatine kinase(CK)and aspartate aminotransferase (AST). Also, there was a significant decreased in the level of serum high density lipoprotein (HDL).Protective activity of camel's milk against toxicity of CCl4  observed in decreasing of TC, TG, VLDL, LDL, LDH, CK, AST and increased in the HDL levels. Conclusion:  These findings strongly prove that beneficial effects of Camel Milk clearly shown through the reduction of the CCl4 induced related damages and oxidative stressKeywords: Camel milk, Carbon tetrachloride, Lipid profile, Rats.
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