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Abdulsamie H. Altaee
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Medicine & Pharmacology

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Association of -34 T > C CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia in Babylon Province, Iraq Abdulsamie H. Altaee
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Benign prostatic hyperplasia (BPH) is the most common benign tumor in men, and its incidence is age-related. This study aims to investigate the effect of -34 T > C CYP17 gene polymorphism on BPH susceptibility and clinical progress.Fifty males patients with BPH clinically diagnosis attended to Al-Hillah Teaching Hospital, as well as fifty males apparently healthy control in a case-control study were subjected to present study. The -34 T > C CYP17 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.Genetic analysis of -34 T > C CYP17 gene polymorphism shows a significantly higher difference when comparing patients with the control groups. The dominant and codominant models of -34 T > C CYP17 gene polymorphism were shown significant change when compared with healthy control The T/C-T/T is genotyping responsible and related to the risk of BPH.In conclusion, -34 T > C CYP17 gene polymorphism could have an important role in the development and pathogenesis of BPH.Kewords: Benign prostatic hyperplasia, CYP17 gene polymorphism, PCR-RFLP, Babylon, Iraq.
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