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Hakimeh Zali
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Medicine & Pharmacology

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Anticancer Properties of Amniotic Membrane Epithelial Cells Hakimeh Zali
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Cancer is one of the important causes of mortality worldwildly. Abundance ofunsuccessful therapeutic methods, their side effects and the high cost of treatments, have led scientific societies to search novel targeting treatments. Anticancer properties of amniotic epithelial cells were emphasis previously, so in this study will review the anticancer factors secreted from this cell. These releasing factors including TNF-α, TNF-β, TGF-β, GM-CSF, NTF3, CCL18, BDNF, GCP-2, IL 2, 4, 6, and 8 induced apoptosis process in a variety of cancer cells. In sum up, this kind of stem cell with anticancer molecule are appropriated to use directly in cell therapy of cancer or indirectly use condition medium.
Bioinformatics Analysis of HSP90 in Amniotic Fluid and Amniotic Membrane Cells as A Potential Anticancer Drug Target Hakimeh Zali
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

HSP90AA is a crucial protective chaperon protein in normal and cancer cell. It has been previously determined HSP90AA down regulate in tumor cell treated with extract of amniotic membrane (AM) stem cells. Aim of this study find out the pathways and molecules associated with reduction of HSP90AA by bioinformatics methods. Network analysis defined the principal functions of HSP90AA in cancer survival and proliferation through interaction with important proteins with different functions such as AR, AKT, HIF1A and P53 to promote tumor cell proliferation and angiogenesis. Gene ontology analysis released the regulation of nitric oxide synthesis activity. In sum up results distinguished the misexperssion of HSP90AA may due to down-regulation of its transcription factors or systemic changes in gene expression of cancer cell after treated with extract of AM cells and induce apoptosis in oxidation state.Keywords: Hsp90AA, Cancer, Amniotic membrane, Epithelialstem cells, Mesenchymalstem cells, Apoptosis
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