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Irina A Balandina
Department of General, Topographic and Clinical Anatomy and Operative Surgery, Perm State Medical University named after Academician E. A. Wagner, 26 Petropavlovskaya st., 614990 Perm, Russia
Medicine & Pharmacology

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Morphological Features of Human Cerebellar Cortex in Old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of the study is to establish regularities of age changes in the structural organization of thecerebellar cortex in old age as compared to young age by using necropsy material. Craniometrical,organometric, histological, immunomorphological and morphometric studies of the cerebellar cortex in219 human corpses (108 men and 111 women) aged from 18 to 44 years and from 75 to 90 years.Comparative analysis of the parameters of Purkinje’s cells in these age groups revealed a decrease in theneurons’ height and width. It was found that the distance between the bodies of the neurons of ganglioniclayer increases with age, which is obviously due to the progressing disorganization and apoptotic death ofPurkinje’s cells. An increase in the number of astrocytes immunopositive to glial fibrillary acidic protein,S-100 protein and vimentin in the granular and molecular layers of the cerebellar cortex is observed, aswell as a decrease in the number of Purkinje’s cells immunopositive to neuron-specific enolase andimmunonegative to S-100 protein and vimentin, which can be considered as a manifestation ofneurodegeneration. Immunohistochemical techniques provide a more differentiated approach to themorphological assessment of the cerebellar cortex in old persons and make it possible to get moreobjective and complete information about the postnatal morphogenesis.
Regularities of Organometric Characteristics of Cerebellum in Young and old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The interest in morphological studies of cerebellum in different periods of postnatalontogenesis is steadily increasing. The most acute lack of age anatomy data exists for elderly patients.Since the information on structural peculiarities of cerebellum and its cortex at old age is poorlyrepresented in literature, being also contradictory in many ways, the study underlying the current paperwas dedicated to this issue. Aims: The purpose of the study was to find regularities of age-relatedchanges in organometric parameters of cerebellum and structural organization of its cortex at old age ascompared to the young age at old age as using necropsy material. Methods: The paper is based onmorphological study of cerebellums of 219 human corpses (108 male and 111 female) of young and oldages using organometric, histological and morphometric research methods. The study includedcomparative analysis of the mass, linear dimensions, thickness of the cerebellar cortex in young and oldages. Results: The regularities of age variability of organometric characteristics of cerebellum wereidentified, manifested in reduction of its weight and linear dimensions in people of senile age comparedto younger people. It was found that the thickness of molecular and granular layer of cerebellum ischaracterized by age-related decrease in parameters. Conclusions: The results of this morphologicalstudy can serve as a basis for identifying specific regularities of age anatomy of cerebellum and havepractical significance as standard indicators, which will allow using these data for diagnostic andtherapeutic purposes.
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