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S. Aparna
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Medicine & Pharmacology

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Analytical Method Development for Sacubitril and Valsartan in Combined Pharmaceutical Dosage Forms by RP-HPLC S. Aparna
Journal of Global Pharma Technology Volume 09 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

The Present work was to develop a simple, fast, accurate, precise, reproducible, Reverse Phase High Performance Liquid Chromatographic Method for simultaneous estimation of Valsartan and Sacubitrilin pure drug form. Chromatographic separation was done using Terrosil C18 column having dimension of (100 mm x 4.6 mm) having particle size of 5.0 µm, with mobile phase consisting of Phosphate buffer (KH2PO4 and K2HPO4) pH 3 ±0.02 pH adjusted with ortho phosphoric acid and Acetonitrile (25:75 %v/v), flow rate was adjusted to 0.8 ml/min and detection wavelength at 254nm. The retention times of Valsartan and Sacubitril was found to be 2.589 and 3.711mins.  The no. of theoretical plates is 4456, 582.and the tailing factor is 1.4, 1.3.Keywords: Valsartan, Sacubitril, RP-HPLC, Method development.
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