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Hussein Kadhem Al-Hakeim
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Medicine & Pharmacology

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Correlation of Serum Dynorphin /KOR System with Serum IL-6 and IL-10 in Major Depressive Disorder Hussein Kadhem Al-Hakeim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A case-control study was applied to improve if there is a relation between endogenous opioid dynorhpin (Dyn) and its receptor KOR with serum interleukin-6 (IL-6) and interleukin-10 (IL-10) among MDD patients versus a group of apparently healthy subjects.  The study included 60 depressed pretreatment male patients and 30 (age and gender matched) controls. The serum Dyn, KOR, IL-6 and IL-10 levels were measured and the relation between these factors was obtained in addition to comparison of these factors between MDD patients and control group. Each parameter was determined by using ELISA technique. The comparison between both groups indicated a significance increase (p<0.05) in Dyn, IL-6 and IL-10 in MDD group comparing with controls. Whereas KOR didn’t show any significant difference. The correlation results indicated that there was no correlation between the two systems (endogenous opioid and immune systems). The conclusion of the study is that there was no relation between Dyn/KOR with inflammatory marker IL-6 and IL-10. This finding indicates that there is no effect of endogenous dyn on the immune function.
Correlation of Serum Cu and Zn with Some Cytokines in Major Depressive Disorder Hussein Kadhem Al-Hakeim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

There is an association of major depressive disorder with different changes in the immune functioning which associate with activation of inflammatory processes. Trace elements such as copper (Cu) and zinc (Zn) have many physiological functions. In the present study, serum levels of Cu, Zn, inflammatory (IL-6), and anti-inflammatory (IL-10) cytokines have been measured in MDD patients and compared with the apparently healthy group. The correlation between the measured trace elements and IL-6 and IL-10 is another purpose of the study to find out the trace elements effect on the secretion of the interleukins in MDD patients. The study involved 60 pretreatment males with MDD and 30 apparently healthy as controls (age matched). The results indicated that there was significantly increase (p
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