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Richard Lobo
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Medicine & Pharmacology

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Investigation of Anti-Inflammatory Potentials of Terminalia Tomentosa Wight & Arn. Bark - An In-Vitro Approach Richard Lobo
Journal of Global Pharma Technology Volume 09 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Terminalia tomentosa bark. Belongs to the family Combretaceae. Bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis and diarrhea.This study establish the anti-inflammatory activity of ethanolic (TEA) and aqueous (TEW) of T. tormentors aback extracts in in-vitro methods by Inhibition protein denaturation (BSA),Inhibition of Egg Albumin denaturationand The human HRBC membrane stabilization method., alcoholic and aqueous extracts exhibited significant protein denaturation inhibition in egg albumin assay with IC50 values TEA113µg/mL, TEW 112.67µg/mL in comparison with Standard (Diclofenac sodium) 236.7µg/ml. In bovine serum albumin denaturation assay with IC50 values TEA 16.91µg/mL and TEW 17.67µg/mL respectively when compared with standard (Diclofenac sodium) 67.21µg/mL. Both alcoholic and aqueous extracts were shown to have membrane stabilization properties with the IC50 values TEA 92.95µg/mL, TEW 37.68µg/mL respectively, in comparison with standard (Diclofenac sodium) 47.48µg/mLTo conclude, this study shows that the T. tormentors, possess significant anti-inflammatory activity.Keywords: Terminalia tomentosa, Anti-inflammatory, Combretaceae, HRBC, Egg albumin Protein denaturation. 
Evaluation of Antimicrobial Activity OF Acalypha Indica Against Various Enteric Gut Pathogens Richard Lobo
Journal of Global Pharma Technology Volume 09 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aimed to identify the photochemical constituents and possible microbicidal potential of ethanol and aqueous extract of Acalyphaindica leaf extract on various gut pathogens. Shade dried leaves of Acalyphaindicawere extracted with solvents of increasing polarity. In vitro anti microbial activity of the water and alcoholic extracts of A. indica was performed by agar punch well diffusion method on selected gut pathogens. Photochemical study of the extracts of A. indicareveals the presence of phytoconstituents like alkaloids, phytosterols, carbohydrates and gums and mucilage’s. Both the aqueous and ethanol extracts showed good to moderate activity against Plesiomonasshigelloide, Shigellaflexineri, Klebsiella pneumonia, Vibrio cholera and Staphylococcus aureus. From the about results we conclude that, the traditionally used medicinal plant A.indica can be useful against the disease causing gut pathogens Keywords: Antimicrobial activity, Acalyphaindica, Gut pathogens, Agar diffusion method, Photochemical screening. 
Anti-Cancer Potential of Vateria Indica L. Stem Bark Enriched Fractions in EAC and C6 Cell lines-an In-Vitro Study Richard Lobo
Journal of Global Pharma Technology Volume 09 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

The western Ghats of India present Pharmacognosists and botanist a rich source of biological diversity to explore their unearthed potential. V. indica, one among the thousands of such plant growing in the southern states of India especially in Kerala, Karnataka and Tamil Nadu, at about 750 m altitude is a slow growing plant of Dipterocarpaceae family. The present study was aimed to investigate the anticancer potential of stem bark of Vateria indica by trypan blue exclusion method and Sulphorhodamine B assay against C6 and EAC cell lines respectively. From the studies it was found that the acetone fraction of V. indica demonstrated high activity whereas ethanolic and petroleum fraction were moderately active against C6 cell lines respectively. It was also observed that the ethanolic and ethyl acetate fraction of V. indica were highly active whereas petroleum ether extract was moderately active against EAC cell lines.Keywords: Vateria indica, Anticancer potential, SRB assay.
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