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Ghassan M. Sulaiman
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Medicine & Pharmacology

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Evaluation of Antioxidant Efficiency of Nanosized Quercetin: An In Vitro Study Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Quercetin is a bioactive compound that is widely used in botanical medicine due to its powerful antioxidant activity. This work aims at encapsulated of quercetin into PLGA nanoparticles by using the nano participation technique. Following by the valuation of their functionality as antioxidant activity. Quercetin and quercetin nanoparticles by using straight forward in vitro free radical scavenging systems including DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical-scavenging assay and hydrogen peroxide radical scavenging. Quercetin nanoparticles showed strong scavenging effects against DPPH, hydrogen peroxide and this effect was more potent than pure quercetin. The scavenging activity of quercetin nanoparticles was concentrations dependent in the range of 4-12 µg mL-¹ showing maximum activity of 90% at 12 µg- mL-¹in similar way to Vit.C which was used as positive control. In conclusion, this work displayed that quercetin exhibited antioxidant activity and could be considered as a source of antioxidants from nature.Keywords: Quercetin nanoparticles, Antioxidants, DPPH, DNA damage.
Production, Purification and Characterization of Laccase from Pleurotus ostreatus Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Laccases are a model for multi copper oxidases and contribute in several applications such as biopulping textile, bioremediation, food industries and pharmaceutical compounds. In this work, factorial parameter was used to study the optimization of production conditions yielded an enzyme .The fungal laccase which produced by Pleurotus ostreatus using barley bran under optimization condition by solid state fermentation was purified by DEAE-Cellulose (IEXC) and this purified laccase enzyme was effected to pH and temperatures to determine the pH optimum and temperatures for laccase activity using syringaldazine as substrate. Results showed that the optimal conditions for enzyme production were incubation temperature: 35 oC, inoculum size: 3mm discs moisture ratio: 1: 10 W\V, Incubation period: 22 days. Whereas the optimal enzyme activity was at temperature 45°c and the enzyme remain stable at the same temperature.  Further the optimal pH for enzyme activity at 5.6 and more stable in pH 6.6.Keywords: Laccase, Pleurotus ostreatus, Optimization, Laccase production.
Nano - Structured Hesperidin: Evaluation the Antioxidant Activities In Vitro Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Hesperidin from citrus peels is known to have anti-inflammatory, vaso-protective, hypo-lipidemic, anti-allergic, anti-carcinogenic and antioxidant actions. Current study was designed to evaluate the antioxidant capacity of hesperidin and hesperidin nanoparticles by using simple in vitro free radical scavenging system including, DPPH free radical-scavenging, hydrogen peroxide scavenging and Resazurin dye scavenging activities. Hesperidin nanoparticles showed strong scavenging effects against DPPH, hydrogen peroxide and Resazurin dye, and this effect was more potent than pure hesperidin. The scavenging activity of hesperidin nanoparticles was concentrations dependent, in the range of 100-400 µg mL-1showing a maximum activity of 80% at 400 µg mL-1in similar way to Vit.C which was used as positive control. In conclusion, this work displayed that hesperidin exhibited antioxidant activity and could be considered as a source of antioxidants from nature.Keywords: Hesperidin nanoparticles, Antioxidants, Resazurin, DPPH, Hydroxyl.
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