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Mohammed S. K. Albermani
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Medicine & Pharmacology

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In-vitro Study of Layer Double Hydroxide Nanoparticles as Effective Carrier to Fight Breast Cancer Growth Mohammed S. K. Albermani
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Vinblastine is well known alkaloid chemotherapy to treat various types of cancer including breast cancer, merging the field of nanotechnology and therapeutic drugs have brought a great interest. However nanodrugs delivery system has been given great attention in this field especially cancer-drug delivery system due to its significant properties which can be increased drug loading, reduced side effect of the drug and suppress cancer proliferation. Layers of magnesium and aluminum layered double hydroxide nanoparticles (LDH) have been synthesized by co-precipitation method with 25 to 50 nm size as SEM has revealed. Vinblastines have been intercalated in to LDH by ion exchange. Breast cancer cell line  MCF-7 have been  used to determine the cytotoxicity of Vin-NPs via MTT survival assay at different time interval 24 hrs, 48 hrs and 72 hrs. Cell viability of MCF-7 through MTT assay suggests drug intercalated LDHs has better drug delivery vehicle for cancer cell line against poor bioavailability of the pure Vinblastine. These observations clearly demonstrate that Vinblastine intercalated LDH NPs is a potential drug delivery vehicle for anticancer drugs which can increase drug efficiency , reduce the side effects and reduce the cost of the drug as well.Keywords:  LDH nanoparticles, Vinblastine sulfate, MCF-7 cell line and MTT assay.
Vinblastine Based Iron Oxide Nano Drug Delivery System Mohammed S. K. Albermani
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Magnetic nanoparticles are a class of nanoparticles with significant properties which make them a highly promising to contribute in a drug design. The size depend property is the key issue that nondrug delivery system relaying on as well as the size of these submicron nanoparticles compared with the volume ratio. Many researchers in the being time focusing on the use of the innovated property of Magnetic nanoparticles applications in drug delivery systems due to their stability and biosafety compared with the others nanoparticles. Hence  Iron Oxide have been chosen for this study and formulated by co-precipitation method with the size ranging between 50-100 nm in diameter the size and the morphology of the iron oxide were conformed using SEM. Vinblastine sulfate which is well known as a powerful chemotherapy against cancer have been incorporated with the iron oxide NPs and tested on MCF-7 a breast cancer cell line at different intervals of time 24hrs, 48hrs and 72hrs, a bright field and fluorescent  image was taken to show the health growing of the cells. MTT survival assay have been conducted to measure the cytotoxity of the iron oxide-vinblastine and compare it with the pure vinblastine. The entire Vin- Fe3O4have shown more efficiency to inhibit the growth of MCF-7 cell line compared with the pure vinblastine. This formulation can be considered as a useful functional drug to cure cancer.
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