Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Global Pharma Technology
Mohamad J. Al-Jeboori
Unknown Affiliation
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Synthesis, Spectral Characterization and Biological Activity of Dithiocarbamate-based Ligand and its Metal Complexes Mohamad J. Al-Jeboori
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This work is based on the synthesis, structural characterization and biological activity of somedithiocarbamate-based complexes. The free dithiocarbamate ligand was prepared via several synthetic routesincluding the formation of Schiff-base. The reaction of 2,6-diaminopyridine with benzaldehyde resulted in theformation of Schiff-base which reduced to the corresponding diamine by methanolic NaBH 4 . The reaction ofdiamine with CS 2 in a methanolic solution of KOH resulted in the preparation of the free dithiocarbamateligand. Macrocyclic complexes were formed from the reaction of the appropriate metal chloride with the ligandin an ethanolic medium. The suggested geometries around metal centres were determined using a range ofphysicochemical and spectroscopic techniques. The analytical and spectroscopic data revealed the formationof four and six coordinate complexes. Complexes of the general formula [M(L)] 2 (where M= Fe(II), Co(II) andZn(II) indicated metal centres adopt tetrahedral geometries. Complexes with the general formula [M(L)(H 2 O) 2 ] 2(where M= Mn(II), Ni(II), Cu(II) indicated octahedral structures around metal centres. Biological activity of theligand and its complexes against four strains of bacteria (Escherichia coli (E. coli), Pseudomonas aeruginosa,Bacillus cereus and Staphylococcus aureus) and antifungal activity against two types of pathogenic fungi,Aspergillus niger and Aspergillus parasiticus are tested.Keywords: Dithiocarbamate ligand; Transition metal complexes; Spectral characterization; Biological activity.
Formation, Spectral and Theoretical Studies of 1-(4,4-Dimethyl-2,6-Dithioxo-1,3,5-Triazinan-1-yl)-3-(Diethylaminocarbonyl)Thiourea Mohamad J. Al-Jeboori
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reaction of diethylcarbamic chloride (one mole equivalent), ammonium thiocyanate (two mole equivalents) and thiosemicarbazide (one mole equivalent) in an acetone medium resulted in the formation of the unexpected4,4-dimethyl-2,6-dithioxo-1,3,5-triazinan-1-yl)-3-(diethylaminocarbonyl)- thiourea3in 83% yield. The chemical structure of the title compound was confirmed by IR, NMR and elemental analysis. Further, a suggested mechanism has been proposed to illustrate the route for the formation of the title compound. In addition, theoretical evaluations of the stable geometries of compound3were carried out using semi-empirical molecular quantum calculations with the PM3 method.Keywords: Thiosemicarbazone, Cyclization reaction, Spectroscopic analysis, Computational calculations.
Co-Authors