Oleh S. Shpychak
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Theoretical Justification of Structure and Development of Capsule Technology with Cerebroprotective Activity Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Treatment of brain remains an urgent problem in the health system in Ukraine, due to the wide prevalence of the most common as a result of this disease causes cerebrovascular diseases, including atherosclerosis and hypertension, leading to a narrowing of the blood vessels of the brain and decreased cerebral blood flow. An alternative method of treatment of cerebrovascular diseases (CVD) it is expected pharmacological effect, which is achieved through use in medicines herbal drug that exhibits antyarytmichal, sedative, tranquilizing, antispasmodic, antiseptic hypotensive effects. According to literature data types such therapeutic activity black horehound grass, the grass dead-nettle herb wormwood and compatible whose presence leads to a potentiation of pharmacological action due to the fact that the components of the content biologically active substances (BAS) show a complex impact on different parts of body systems and increase reliability and predictable therapeutic effect. This complex of action reduces the possibility of side effects of display. The aim of this work is the theoretical basis structure and development of technology for rational drug cerebroprotective action in the form of hard gelatin capsules based on dry extracts medical plant material (MPM), namely black horehound grass, herb nettle deaf, sage herb. On the basis of experimental studies, we have proved the composition of masses for encapsulation of drug in the form of hard gelatin capsules number 0. Composition per capsule: a mixture of dry extracts MPM-400 mg; aerosol-50 mg; lactose monohydrate -50 mg. The weight of the contents of the capsule-500 mg. Keywords: Dry extracts, Development composition and technology, Gelatin capsules, Cerebroprotective activity.
Determination of Standard Parameters of Acorn Squash Leaves Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

One of the priority tasks of pharmacy is to find new sources of raw materials for the medicinal products. The purpose of this work is to determine a number of indicators of the quality of promising medicinal raw materials that are the leaves of acorn squash Cucurbita pepo (Cucurbitaceae) for the creation of regulatory and technical documentation. For our research one of the most competitive kind - "Ukrainian multi-plant" was chosen. This kind is not sensitive to climatic conditions (drought-resistant). It has been grown in many countries with moderate climate and the most parts of Ukraine (Polissya, forest-steppe, steppe) and other since 1950. In this way, for the first time, 7 series of acorn squash leaves of "Ukrainian multi-plant" were studied. The main diagnostic features of morphological structure, including morphometric indicators, the main diagnostic microscopic features of the powder of acorn squash leaves were determined. The work presents the limit values of the main figures of 7 series of raw materials: weight loss during drying (not more than 8.5 %), total ash content (not more than 3.7 %,), extractive substances content (not less than 20.0%), phenolic compounds content (not less than 2.0 %). According to the results obtained the regulatory and technical documentation “Methods of quality control of” Acorn squash leaves “has been developed. Keywords: Acorn squash, Leaf, Morphological structure, Microscopic diagnostic signs, Plant raw materials.