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Arun R
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Medicine & Pharmacology

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Development of analytical method and validation for Nadolol in pure and pharmaceutical formulations using UV-spectrophotometry and spectrofluorimetry using Hydrochloric acid Anton Smith A; Akanksha .; Arun R
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Development of analytical methods is in need for the estimation of drugs in pure and different pharmaceutical formulations. A simple, sensitive, rapid, accurate, precise and economic Spectrophotometric and Spectrofluorimetric method were developed and validated for Nadolol in pure and Pharmaceutical formulations. Methods: The wave length (λmax) used for the estimation of Nadolol is 267nm by Spectrophotometry, excitation (λEx)-267nm and emission (λEm)-300nm by Spectrofluorimetry. Results: Linear correlation was obtained between absorbance and concentration of Nadolol in the concentration ranges of 20-60µg/ml with R2 value 0.998 by Spectrophotometry and linear correlation was obtained between intensity of fluorescence and concentration of Nadolol in the concentration ranges of 1-5µg/ml with R2value 0.993 by Spectrofluorimetry in 0.1 N HCl.  The linearity of the calibration curve was validated by the high values of correlation coefficient of regression. LOD and LOQ values for Nadolol were found to be 3.95µg/ml and 11.99µg/ml by Spectrophotometry and 0.90µg/ml and2.74µg/ml by Spectrofluorimetry. Conclusion: Among the two developed methods Spectrofluorimetric method is highly sensitive than the spectrophotometric method. These methods are simple and suitable for the determination of Nadolol in pure and Pharmaceutical preparations.
Co-Authors Akanksha . Anton Smith A