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Mahmoud Mirhosseini
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Medicine & Pharmacology

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Medicinal Plants with Anti-Poisoning Toxicity of Carbon Tetrachloride: An Overview of the Most Important Medicinal Plants Native to Iran with Anti- Carbon Tetrachloride Toxicity Mahmoud Mirhosseini
Journal of Global Pharma Technology Volume 08 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

One type of the liver poisoning is poisoning with carbon tetrachloride. Carbon tetrachloride-induced liver damage is related to the toxic agent which is metabolized by the NADPH-cytochrome P450 enzyme system to reactive radicals including trikler and methyl- o- proxyler. One of the available remedies to protect liver is the use of medicinal plants. Since in Iran liver protective drugs are less available, then the use of available natural remedies that have fewer toxic side effects than chemical drugs seems necessary. In the present study, medicinal plants native to Iran have been reviewed and reported which have liver protective effect against toxicity induced by carbon tetrachloride as a factor causing human poisoning. In this review study, literatures were searched with key words including liver toxicity, carbon tetrachloride, herbs, extracts, and essential oils. The papers were searched from databases inside and outside Iran including Google Scholar, SID, MegaIran databases, and a number of other databases. Based on the results, medicinal herbs such as grape, oak, Aucheri, pistachio, Fumaria, and milk thistle are anti-poisoning plamts against carbon tetrachloride. Since the active ingredients of the mentioned plants have been specified in the phytochemical studies, then catechin, epi-catechins, epi-3-gallate catechin, mucilage, calheritrin, fumaric acid and an alkaloid called fumarinkoerist, and nitrose amine are probably the active ingredients against carbon tetrachloride poisoning.Keywords: liver, Poisoning, Carbon tetrachloride, Herbs, Iran
A Review on the Most Important Medicinal Herbs Native to Iran with Anti-Acetaminophen Toxicity Mahmoud Mirhosseini
Journal of Global Pharma Technology Volume 08 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

Acetaminophen is an analgesic and anti- fever drug, which can be toxic in high doses and leads to hepatic and renal injury. Acetaminophen poisoning can cause many complications and injuries in the body including vomiting, diarrhea, malaise, shock, jaundice, and liver failure and in some cases will lead to myocardial and kidney damage. Against all toxic and destructive effects of drugs like acetaminophen, some compounds are found that can partially restrain poisoning of abuse such compounds. In this review article, medicinal plants native to Iran have been reported, which are used to protect acetaminophen toxicity. In this review study, searching the articles with key words such as acetaminophen, hepatotoxicity, herbs, extracts, and essential oils were used. Searching the articles was conducted through databases of income in Iran like Google Scholar, ISI January, MegaIran, and a number of other databases. Medicinal plants including green tea, turmeric, cress, dandelion, and capers are the most important medicinal plants against the toxicity of acetaminophen. It seems that pharmacological bioactive and antioxidants substances obtaining from plant and biological materials are anti- acetaminophen poisoning.Keywords: liver, Toxicity, Acetaminophen, Herbs, Iran.
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