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Husam M. Kredy
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Medicine & Pharmacology

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Clinical Study of Vitamin D3 Deficiency and some Trace Elements in Autism Husam M. Kredy
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Autism is a disorder of nerve growth characterized by weak social interaction and verbal and nonverbal communication, as well as restricted behavior and stereotypes. The subjects of the study were 90 autistic children with varying degrees of severity (mild, moderate and severe) who were diagnosed with DSM-IV, thirty children in each group and 30 healthy children (age and sex were identical). The boys and girl ratio involved in this study was 4:1, and they were 4-12 years of age. The study showed a significant elevation in the levels of Cu and Pb in the blood sample of autistic children when compared to a healthy control group. The elevation was much pronounced in severe group subjects when compared among autistic groups mild and moderate. The levels of Zn and Vitamin D3 were significantly decreased in autistic children when compared to control. The Zn and Vitamin D3 showed significant variation in blood of severe group children when compared to control group and other study groups. The correlation between Zn and Vitamin D3 in these patient groups were positive. Whereas the correlation between Zn and each of (Cu and Pb) in these patient groups were negative.Keywords: Autism, Children, Blood, Trace Elements, Vitamin D3.
Synthesis of a New Bicyclicgamma Lactam and Evaluation of their Anticancer Activity Husam M. Kredy
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Highly diastereoselective synthesis of γ-lactams 5(a-b) based on the reaction of imines 3(a-b) with phenylsuccinic anhydride is described in this study in moderate yields. The synthesized compounds were tested in vitro for their antioxidant activity. The prepared compounds showed an antioxidant activity. Anticancer activity of the compounds 3(a-b) were tested against breast cancer cells (MCF7), which showed high efficiancy against MCF7 cell lines . The compounds were determined on the basis of the spectral studies using IR, 1H-NMR and13C-NMR.Keywords:  γ-lactams, Antioxidant, Anticancer, MCF7.
Extraction of Poly Phenols from Cladium Mariscus Seeds and studying its Antifungal Activity with Isolation and Identification of one Compound of Flavone Glycosides Husam M. Kredy
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Cladium mariscus is one of the plants belonging Cyperaceae family. It is a common plant in AL- Hammar marshes, eastern - south of Iraq. The aim of the present study was extraction poly phenols from C. mariscus seeds by using an ultrasonic-assisted extraction method. The yield of poly phenols extracted by this method was (0.43% w/w). One compound was isolated from the methanolic extract of the plant seeds. The structure of the new compound was identified via the basis of extensive spectroscopic analyses (UV-Vis, IR, 1H NMR, and Mass),  and some chemical test. Acacetin glycosides were expected compound, and the methods of spectroscopy showed that there are three molecules of hexagonal sugars linked with aglycone. The antifungi activity of methanolic extract was examined against fungus: A.flavus, A.fumigatus and C.albicans, by using the well disk diffusion method. The extract showed a clear inhibition effect against fungal at (50 %, 75 % and 100 % w/v) concentrations.  Key words: Ultrasound-assisted extraction, Cladium mariscus, Acacetin glycosides, Antifungal.
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