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All Journal MEDICINUS Journal of Global Pharma Technology
Heru Sutanto Koerniawan
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Lack of Association between Hypercholesterolemia and Obesity Status with the Gallstones type among Cholelithiasis Patients at Sanglah General Hospital, Bali, Indonesia Heru Sutanto Koerniawan
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Gallstone disease is still one of the major health problems in the world. It is one of the most common diseases in developed countries associated with many factors. Increased total blood cholesterol, free cholesterol, LDL, triacylglycerol, obesity, and decreased HDL cholesterol levels also play an important role in the pathogenesis of gallstone formation. This study aimed to determine the relationship between hypercholesterolemia and obesity to types of gallstones. Methods: An observational cross-sectional study was conducted at Sanglah General Hospital from January-December 2017. The sample was obtained using consecutive sampling of patients with cholelithiasis that met inclusion and exclusion criteria. Data analysis was done with univariate and bivariate analysis using SPSS version 23 software. The confidence interval was set to 95% and p-value < 0.05 was considered statistically significant. Result: Twenty-six samples were included in this study. Majority of the sample was suffered from gall stone type cholesterol and was performed open cholecystectomy. There was no association found between gall stone type and obesity (p=0.618). In addition, recent findings also suggest no significant differences between gall stone type and total cholesterol status (p=0.211).Conclusion: There is no association between obesity and hypercholesterolemia with gall stone type in cholelithiasis patients.Keywords: Cholelithiasis, Gallstone, Hypercholesterolemia, Obesity.
Hubungan Antara Obesitas dan Hipertensi dengan Kanker Payudara pada Pasien di Rumah Sakit Siloam Lippo Village Gedung B Nicoline Naomy Lamria; Heru Sutanto Koerniawan
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/t7vk9k12

Abstract

Background: Breast cancer has become one of the most common cancers in Indonesia, and being one of the largest contributors to cancer deaths. Several studies have shown association between breast cancer with obesity and hypertension, both as modifiable risk factors. Methods: This study was conducted using unpaired categorical comparativeanalytic method with a case control design. Samples were collected using medical record data using consecutive sampling method. Sample were 160 patients aged 20–55 years at Siloam Lippo Village Hospital Building B; consisting of 80 casegroup samples and 80 control group samples. Data was analysed using Chi-square test. Result: Data analysis resultshowed that there was an association between obesity and breast cancer in patients at Siloam Lippo Village Hospital Building B (p=0.000; OR=11.238; 95% CI=5.360–23.563). There was also association between hypertension and breast cancer in patients at Siloam Lippo Village Hospital Building B (p=0.007; OR=7.567;95% CI=1.648–34.740). Conclusion:There is a significant association between obesity and hypertension with the incident of breast cancer in patients at SiloamLippo Village Hospital Building B.
Co-Authors Nicoline Naomy Lamria