Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Global Pharma Technology
Ahmed Yousif Rmaidh
Unknown Affiliation
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Synthesis, Characterization and Antibacterial Activities of Some Heterocyclic Compounds from valproic Acid Drug Ahmed Yousif Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

With a view to reducing the acidic effect of valproic acid, its carboxylic group has been recoated to produce 5-membered and 6-membered heterocyclic rings. Heterocyclic derivative as -Thiadiazole, Imidazole, -Oxazine, Quinazoline, Pyrazole and Oxadiazole. Derivatives of valproic acid were prepared by cyclization under different reaction states to produce a good yield. The microbial inhibitory effect of these compounds was assessed in vitro against Gram-positive and Gram-negative bacteria as well as tested against two strains of bacteria (Escherichia coli and Staphylococcus aureus compared with starting material. Compounds (4, 5, 8) showed the highest antibacterial as well as antifungal activities. All compounds have been characterized by IR, 1H NMR and C.H.N analysis.Keywords: Valproic acid, Thiadiazole, Imidazole,-oxazine, Quinazoline, Pyrazole, Oxadiazole, biologically active compounds.
Co-Authors