Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Global Pharma Technology
Meaaad Nasser
Unknown Affiliation
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Study the Effect of Some Heterocyclic Compounds on the Cholinesterase Enzyme in Human Blood Serum Meaaad Nasser
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This research involve synthesis  of three  type of heterocyclic derivatives (thiadiazole, thiadiazole-shiff base, thiadiazole-azo) by three step, the first step react p-hydroxybenzoic acid with thiosemicarbazide to get compound (1), the second step include react (1) with (p-chloro benzaldehyde, p-hydroxy benzaldehyde) to get thiadiazole-shiff base derivatives (2,3) respectively, in other side the third step involve react (1) with 1-naphthol and salicylaldehyde to get, thiadiazole-azo derivatives (4,5) respectively, all these derivatives were characterize  by FT-IR, 1H-NMR, 13C-NMR  spectra .After that the effect of these compounds was studied  on the activity of the enzyme acetyl cholinesterase in the human serum. Compounds that have the donated  groups in the ring  showed a high inhibition ratio, either the compounds containing the withdrawing groups in the ring showed a low inhibition ratio because  the effect of resonance.Keywords: Thiadiazole, thiadiazole-shiff base, thiadiazole-azo, cholinesterase
Co-Authors