Dennely Yulisa
Universitas Katolik Indonesia Atma Jaya

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Pengaruh Paparan Cahaya Biru terhadap Penuaan Kulit dan Upaya Pencegahannya Dennely Yulisa
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p179-186.2023

Abstract

Penuaan merupakan sebuah proses yang akan dialami individu seiring bertambahnya usia. Penyebab penuaan yang mungkin masih belum disadari adalah penuaan yang disebabkan paparan cahaya biru. Hal ini menjadi sebuah isu yang menarik berkaitan dengan meningkatnya penggunaan perangkat elektronik di berbagai kalangan usia. Cahaya biru memiliki efek merugikan pada homeostasis kulit, yaitu meningkatkan produksi ROS, mediator inflamasi, dan menyebabkan kerusakan DNA, sehingga tubuh mengupayakan efek antiproliferatif seperti menginduksi aktivasi melanogenesis, mengurangi produksi kolagen, mengubah aktivitas metalloproteinase, yang menyebabkan photoaging dan hiperpigmentasi. Meningkatnya kesadaran akan efek cahaya biru pada tubuh menyebabkan munculnya berbagai produk yang menyatakan dapat memberikan perlindungan terhadap cahaya biru. Beberapa upaya pencegahan yang dapat dilakukan adalah dengan melakukan fotoproteksi, menggunakan tabir surya yang mengandung zinc oxide dan titanium dioxide. Berbagai bahan kosmetik, antioksidan dan vitamin juga diduga dapat memberikan efek proteksi terhadap cahaya biru. Upaya pencegahan terhadap cahaya biru sampai saat ini masih terus berkembang dan membutuhkan penelitian lebih lanjut.
Re-Emerging Outbreak, Smallpox Vaccination for Monkeypox Infection: A Systematic Review Maureen Miracle Stella; Franklind Matthew; Dennely Yulisa; Novitasari, Novitasari,; Janice Suhartono; Regina Regina
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.1761

Abstract

Monkeypox disease is caused by the monkeypox virus (MPXV) infection and is associated with international travel or imported animals. Since May 2022, the number of newly reported cases each week has increased dramatically, leading the WHO to declare this outbreak as a public health emergency of international concern. To evaluate antibody response and disease status after monkeypox vaccination using the smallpox vaccine. The authors followed the PRISMA guidelines to systematically search and collect literature from the following databases: ProQuest, PubMed, EBSCOhost, SAGE, Taylor & Francis, and GARUDA without time restrictions. Titles and abstracts were reviewed for relevance. The inclusion criteria were original articles written in English that investigated the effects of smallpox vaccination on MPXV infection. A total of 973 studies were initially identified through database searching. After removing duplicates and screening titles and abstracts based on the predefined inclusion and exclusion criteria, potentially relevant articles were assessed through full-text review. Following this eligibility assessment, 30 studies were included in the final analysis. These included cohort studies (n=1), case-control studies (n=1), case reports (n=1), and in vivo studies (n=27) published between 2002 and 2022. Two types of smallpox vaccines were used: live attenuated vaccines (n=24) and subunit vaccines made from protein (n=1), virus-like replicon particles (n=1), and DNA virus (n=5). The overall results showed that post-exposure vaccination protected subjects and could induce long-term protection against severe MPXV infection. Subunit vaccines against MPXV could also serve as a safer alternative to live attenuated vaccines. Smallpox vaccination is recommended for high-risk groups susceptible to monkeypox infection. Specific vaccines for monkeypox infection are still being developed. This systematic review found that the overall potential of smallpox vaccines is quite satisfactory in preventing MPXV infection.