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All Journal Journal of Pharmaceutical and Health Research
Waffiyyatul Mardiyyah
Sekolah Tinggi Ilmu Kesehatan Bani Saleh, Bekasi
Health Professions Medicine & Pharmacology Nursing Public Health

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Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan Sari Defi Okzelia; Waffiyyatul Mardiyyah
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2892

Abstract

Dry skin is the most common skin problem, so moisturizers are used to prevent it. White skin (mesocarp) of watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] (MW) has the potential to be formulated into a moisturizing gel preparation since it contains vitamins and citrulline which also possess antioxidant activity. This study aimed to formulate a moisturizing gel preparation from MW extract as an antioxidant. MW was extracted by maceration using 70% ethanol and formulated into moisturizing gel preparation at concentrations of 5% (F1), 10% (F2), and 15% (F3). Gel preparations were evaluated physically, and determined their moisture content and antioxidant activity. MW extract was a brown color with 25.02% yield. The evaluation results showed that all formulations met the standard parameters of good gel preparations including organoleptic, homogeneity, spread-ability, adhesion, pH, and viscosity, and did not irritate the skin. The skin moisture after application of F1, F2, and F3 respectively were 29.49%; 36.63%; and 43.48%. IC50 values for F1, F2, and F3 respectively were 156.42; 149.24, and 138.05 µg/mL. The moisturizing gel preparation from MW extract met all the standard parameters of good gel preparation, could increase the percentage of skin moisture, and had moderate antioxidant activity.
Co-Authors Sari Defi Okzelia