The human respiratory system is vulnerable to the impacts of carbon monoxide (CO) emissions, a colorless and odorless gas. The aim of this research is to analyze the CO levels in the air and its relation to regulations governing air quality, specifically referring to Government Regulation Number 22 of 2021. This study also discusses the correlation between CO levels with air temperature and the number of motor vehicles. Measurements were conducted using a CO meter, and manual counting of motor vehicles was included as part of the purposive sampling procedure over a period of 3 days. On Saturdays, the average CO concentration was at its highest point, ranging from 64.131 μg/m3 in the morning to 52.106 μg/m3 in the afternoon and 37.791 μg/m3 in the evening. The average temperatures recorded were 31°C in the morning, 32°C in the afternoon, and 30°C in the evening. There was an increase in CO levels at Hospital X exceeding the permissible limit stated in Government Regulation Number 22 of 2021. Regarding air quality at Hospital Y, CO concentrations were 33.210 μg/m3 in the morning, 11.451 μg/m3 in the afternoon, and 29.775 μg/m3 on Monday afternoon, all of which were above normal levels. With a value of α of 0.000, which is less than 0.01 according to Pearson correlation test, a significant relationship between temperature and CO levels was revealed, with a Pearson correlation coefficient (r) of -0.917. There is a perfect negative correlation between these two variables. To determine the presence of a relationship between the number of motor vehicles and CO concentration, the Pearson correlation test yielded a significant result with a value of α of 0.048 and an r value of 0.670. The correlation between the two variables is evident.