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All Journal Health Media E-Amal: Jurnal Pengabdian Kepada Masyarakat
erlina fatmasari
Program Studi D3 Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin
Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions

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Optimation of Nanocream 3,4-dimethoxychalcone as UVA Protection Agent Used Simplex Lattice Design Method erlina fatmasari
Health Media Vol 4 No 1 (2022)
Publisher : UrbanGreen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/hm.v4i1.127

Abstract

3,4-dimethoxychalcone (3,4-DMT) is a chalcone derivative can be used as a UVA-protection agent but its insolubility in water (log-P 3.84). Therefore, an appropriate delivery system is needed that can increase the solubility and transport of 3.4 DMT through the skin layer. The nanocream formulation was chosen to make chemical sunscreen preparations suitable for water insoluble ingredients. This study aims to obtain the optimal composition of 3,4-DMT in a nanocream formula. Nanocream formulation was carried out using the simplex lattice design method. VCO was used as the oil phase with a mixture of tween 80 and span 80 (Smix) which was mixed using a high-energy-emulsification method. Physical test of nanocream such as pH, spreadibility, viscosity, adhesion, freeze thaw showed result good result and particle size > 200 nm, zeta potential ± 30 mV, PDI < 1; drug content 94.02%-94.90%. Data analysis for all measurements used ANOVA statistical analysis.
UJI IN-VITRO ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN KELAKAI (STENOCHLAENA PALUSTRIS (BURM.F.) BEDD.) TERHADAP BAKTERI PENYEBAB DIARE ESCHERICHIA COLI DAN SALMONELLA TYPHI Siti Saniah; Dinda Puspita Sari; Amar Abdat; Senponi Pebriani; Muhammad Hery Dayesdha Yade; Jordi Setiawan; Erlina Fatmasari
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 3 No 3: September-Desember 2023
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v3i3.2826

Abstract

Kelakai (Stenochlaena palustris (Burm. f.) Bedd.) one of the typical plants of South Kalimantan which has many benefits, not only often consumed as food, also useful as treatment, which is diarrhea disease. This study aims to determine the standardization of simplisia and phytochemical screening of ethyl acetate extract of kelakai leaves and in-vitro antibacterial tests against bacteria cause diarrhea e.coli & salmonella typhi. The research method begins with the preparation of simplisia, ethyl acetate extract of kelakai leaves, in-vitro antibacterial testing against bacteria cause diarrhea e.coli & salmonella typhi with a concentration variation of 12.5%; 25%; 37.5% & 50%. The results obtained on kelakai leaf simplisia are drying shrinkage with an average 7.5%. Water soluble juice content with an average 24% and ethanol soluble juice content with an average 19%. Phytochemical screening of ethyl acetate extract of kelakai leaves is positive for alkaloids, tannins, phenols, saponins, and flavonoids. This study shows antibacterial activity against bacteria that cause diarrhea, namely e.coli and salmonella typhi, has good potential with a concentration of 12.5% as seen from the diameter of the inhibition zone formed including the medium category, which is 10.18 mm in salmonella typhi bacteria and 10.86 mm in e.coli bacteria
Co-Authors Amar Abdat Dinda Puspita Sari Jordi Setiawan Muhammad Hery Dayesdha Yade Senponi Pebriani Siti Saniah