The industrial revolution 4.0 brings changes to the world of education that demands innovation and the use oftechnology and information in learning. The purpose of this research is to produce a teaching material, namelyan electronic module (e-module) on the use of phytochemicals in the field of pharmaceuticals which is orientedtowards chemical literacy. The method used in this research is the Design Based Research (DBR) method. Theresulting e-module presents material in the form of various phytochemical compounds that have bioactivity asanti-cancer, anti-diabetic, and anti-inflammatory along with chemical literacy-oriented questions. The e-moduleis validated by three validators, namely material experts and multimedia experts. In general, the results of the emodule validation are declared valid with a rcount value of 0.77 and are included in the fairly high validity category.