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All Journal Berkala Kedokteran ALKIMIA : Jurnal Ilmu Kimia dan Terapan
Habibah, Hanna
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Magnetic-Hydrochar from Galam Bark Waste (Malaleuca cajuputi) as Sasirangan Waste Adsorbent Habibah, Hanna; Ridwan, Risaldi; Safitri, Desmalina; Sunardi, Sunardi
ALKIMIA Vol 6 No 1 (2022): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (640.053 KB) | DOI: 10.19109/alkimia.v6i1.13629

Abstract

Galam wood (Malaleuca cajuputi) is one of the woody plants that is able to grow well in the peat swamp environment of the South Kalimantan wetlands. Research on the synthesis and characterization of magnetic-hydrochar from galam bark waste for the treatment of sasirangan liquid waste has been carried out. This study aims to determine the characteristics of hydrochar and magnetic-hydrochar against the adsorption ability of sasirangan liquid waste. The results showed that the modification of galam bark into hydrochar and magnetic-hydrochar produced different characteristics based on the analysis of functional groups of infrared spectra. The surface morphology of hydrochar and magnetic-hydrochar also showed the significant differences based on scanning electron microscope (SEM) analysis. The resulting magnetic-hydrochar showed a higher adsorption ability to sasirangan waste than the hydrochar of galam bark and galam bark without modification.
Potential of Chemical Compounds from Coloring Plants (Stenochlaena palutris) as Competitors for ALK Protein Damage Due To Pesticide Exposure: In Silico Study Sarmila, Sarmila; Nafisah, Nafisah; Habibah, Hanna; Saputri, Indah; Setiawati, Indah; Komari, Noer
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17415

Abstract

Pesticide active ingredients have widespread toxicity effects on target and non-target organisms. Continuous exposure to pesticides causes cancer. Kelakai is thought to have potential cytotoxic activity against the growth of cancer cells. The aim of this research is to examine the potential activity of chemical compounds on Anaplastic Lymphoma Kinase (ALK) proteins exposed to organophosphate pesticides in silico. Protein and ligand preparation with the Chimera program, Docking using SwissDock, as well as virtual screening using the pkCSM web and ProTox. Ethion and neophytadiene have the most negative ∆G values of -8.62 kcal/mol and -8.39 kcal/mol, respectively. The binding site for ethion and neophytadiene compounds with the ALK protein is right at the active site of the ALK protein. Ethion is the most toxic organophosphate pesticide and has the potential to be cytogenic. Neophytadiene from kelakai compounds has the potential to act as a competitor in inhibiting the ALK protein. The similarity in the type and number of binding residues in ethion and neophytadiene in the ALK protein indicates competition between ethion and neophytadiene.
Co-Authors Indah Setiawati Nafisah Nafisah Noer Komari Ridwan, Risaldi Safitri, Desmalina Saputri, Indah Sarmila, Sarmila Sunardi Sunardi