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All Journal Medical Clinical Update Journal
Chandni P. Daryanani
Unggul Karsa Medika Teaching Hospital, Bandung, West Java, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Pediatric Dengue Encephalopathy: A Review Ilham Setiorizaldi; Amandianti Arimbi Tedjaningrum; Cindy Grace Panggabean; Enjelina Nangin; Jeffrey Christian Mahardhika; Chandni P. Daryanani
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1648.264 KB) | DOI: 10.58376/mcu.v1i1.5

Abstract

Dengue encephalopathy is a very common neurological complication of dengue fever. Dengue encephalopathy or dengue hemorrhagic fever (DHF) with Central Nervous System (CNS) involvement used to be considered a relatively rare condition. However, the number of cases reported in human studies were increasing every year. Many factors caused the encephalopathy dengue. Possible mechanisms are hepatic failure (hepatic encephalopathy), cerebral hypoperfusion (shock), cerebral edema (vascular leakage) electrolyte disturbances, and intracranial hemorrhage due to thrombocytopenia or coagulopathy, which are secondary mechanisms of hepatic failure. Computed Tomography (CT) scan or Magnetic Resonance Imaging (MRI) of brain can be done to make certain of the diagnosis. The results can suggest the presence of extensive involvement of the bilateral cerebellar region, brain stem, and thalamus along with peculiar rim enhancement. Treatment in Intensive Care Unit (ICU) with a multidisciplinary team is required due to the patients’ decreased level of consciousness, underlying problems of airway, breathing, and circulation, comorbidities, and considerations of specific etiology.
Precocious Puberty: A Case Report Anna Felita; Ivanna Sarahfebi; Anastasia Nadya; Parbati Anjali; Chandni P. Daryanani
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1670.743 KB) | DOI: 10.58376/mcu.v1i1.9

Abstract

Background Puberty is a transitional period in children with acceleration of growth and development of secondary sexual characteristics. When this period appears before the age of 8 to 9 years in children, it is called precocious puberty. Depending on the primary source of the hormonal production, precocious puberty may be classified as central (gonadotropin dependent or true) or peripheral (gonadotropin independent or precocious pseudo-puberty). Case presentation We herein report a case of precocious puberty in a 7,5-year-old girl who has shown early sign of secondary sexual development. Patients complained pain on her nipple, her breasts began to grow in size, and changes in her body odour, but had no complaints about her pubic hair growth and any vaginal discharge. Laboratory findings shown high level in fertility hormones and level of bone age is equal to 10-year-old girl. Patient then had begun to receive monthly therapy of Leuprolide. Conclusion Detailed history taking on chronological order of thelarche, pubarche, menarche, and adrenarche, followed by assessment on family history, nutritional history, child developmental history, medication history, and neurological complaints should be done in order to diagnose precocious puberty. Physical examination and other examination of bone age determination, Luteinizing Hormone and Follicle-Stimulating Hormone level, and pelvic ultrasound are essentials in defining the diagnosis and treatment. Leuprolide is indicated for Central Precocious Puberty patient who have advanced bone age at the time of initial evaluation. As a clinician, it is necessary to diagnose precocious puberty as soon as possible to have good prognosis for the patient.
Co-Authors Amandianti Arimbi Tedjaningrum Anastasia Nadya Anna Felita Cindy Grace Panggabean Enjelina Nangin Ilham Setiorizaldi Ivanna Sarahfebi Jeffrey Christian Mahardhika Parbati Anjali