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Ernawati Ernawati
Bagian Farmakologi Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Hubungan Status Gizi dengan Kejadian Sindrom Metabolik di Dusun Arosbaya, Desa Sabuh Bangkalan Madura Popy Mega Wati; Ernawati Ernawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 1 (2016): Edisi Maret 2016
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.504 KB) | DOI: 10.30742/jikw.v5i1.4

Abstract

Obesity has become a global problem in the world and showed a sharp upward trend. Coincide with the increasing in obesity, also known as metabolic syndrome. Metabolic syndrome (MS) is a complex metabolic disorder caused by an increasing in obesity. Several  groups of studies suggest that obesity, insulin resistance, dyslipidemia and hypertension are the major component MS. Based on data from Public Health Center in Arosbaya-Bangkalan Madura, hypertension, diabetes mellitus, and disorders of lipid metabolism showed a fairly high number of patients in each year. The aim of this research was to analyze the relationship of nutrition status with metabolic syndrome phenomenon in Arosbaya District, Sabuh Village Bangkalan-Madura. This research was an observational study with cross sectional study approach Chi-square statistical test. The samples used were 70 people who are society of Sabuh Village. Variable consists of a Body Mass Index (BMI) as independent variables, and components of the metabolic syndrome that includes waist circumference, fasting blood glucose, triglycerides as the dependent variable. The results showed a significant relationship between nutrition status and some components of the metabolic syndrome (α <0.05). From the analysis it can be concluded that nutrition status has an influence on the phenomenon of metabolic syndrome. Adopting a healthy lifestyle is one of the prevention of obesity and other comorbidities.
Pemanfaatan Seduhan Daun Ashitaba dengan Simvastatin dalam Menurunkan Kadar LDL Tikus Putih Jantan Strain Wistar Ernawati Ernawati; Theresia Ratnasari Widjaja
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.648 KB) | DOI: 10.30742/jikw.v7i1.256

Abstract

High levels of blood cholesterol or hypercholesterolemia is an important risk factor for a cardiovascular disease. In order to overcome this problem, giving statins drug such as simvastatin is an intervention that is often applied. Besides using this drug, it can also be accompanied by consuming herbal plants which is Ashitaba leaves (Angelica keiskei). It contains Chalcones which demonstrates anti tumour property and also antioxidant activity that can lower cholesterol levels, especially LDL in the blood. This study aimed to investigate the effect of Ashitaba leaves (Angelica keiskei) steeping administration in assisting simvastatin drugs to decrease the levels of Low Density Lipoprotein (LDL) in the blood serum of male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. The population for this study was male white rats Strain wistar (Rattus Norvegicus) with samples taken in this study were 33 white rats. Data analysis for this study is using One Way Anova test.The result showed that supplementation of simvastatin treatment using steeping Ashitaba leaves might slightly reduce LDL level among male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. However, the result demonstrated not significant different.  To assist simvastatin drugs in lowering LDL levels in male white rats Strain wistar (Rattus Norvegicus) which is made to be hypercholesterolemia can lower LDL levels slightly but not significantly (p-value = 0,177) which is >a (0,05).
Co-Authors Popy Mega Wati Theresia Ratnasari Widjaja