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All Journal MNJ (Malang Neurology Journal) Indonesian Journal of Life Sciences
Fachriy Balafif, Fachriy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology Neuroscience

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CORRELATION OF SEVERE HEAD INJURY EPIDURAL HEMATOMA TREPANATION RESPOND TIME WITH OUTCOME Santoso, Mochamad Istiadjid Eddy; Rahayu, Masruroh; Balafif, Fachriy
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.549 KB) | DOI: 10.21776/ub.mnj.2016.002.01.3

Abstract

Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (α=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome.Conclusion. Faster trepanation respond time will have better outcome.
The F-11 Sensory Neuron Model: A Scalable In Vitro Platform for Neuropathic Pain and Drug Screening Nazwar, Tommy Alfandy; Laksono, Ristiawan Muji; Balafif, Farhad; Wardhana, Donny Wisnu; Balafif, Fachriy
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.290

Abstract

Neuropathic pain remains a major therapeutic challenge, largely due to the translational disconnect between preclinical animal models and clinical efficacy in humans. This review critically evaluates the differentiated F-11 cell line, a hybridoma of mouse neuroblastoma and rat embryonic dorsal root ganglion (DRG) neurons, as a scalable, reproducible, and physiologically relevant in vitro platform for neuropathic pain research and analgesic drug screening. A detailed analysis of differentiation strategies highlights the critical interplay of neurotrophic factors (notably NGF), intracellular signaling modulators (such as cAMP elevators), and extracellular matrix cues in driving neuronal maturation. Functional validation via calcium imaging and electrophysiology confirms capsaicin responsiveness and action potential generation, mirroring native nociceptors. Its compatibility with medium-to-high-throughput screening and mechanistic studies including investigation of silent nociceptor sensitization in chronic pain conditions along with emerging applications in neuropathy models, makes it a valuable tool for de-risking drug candidates before animal studies.
Co-Authors Balafif, Farhad Masruroh Rahayu, Masruroh Nazwar, Tommy Alfandy Ristiawan Muji Laksono Santoso, Mochamad Istiadjid Eddy Wardhana, Donny Wisnu