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All Journal JURNAL KIMIA SAINS DAN APLIKASI
Fauzy Rachman
Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Jl. Raya Jakarta-Bogor Km. 46, Cibinong-Bogor, West Java 16911|National Research and Innovation Agency|Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Antioxidant and Anticancer Activities of Sand Sea Cucumber (Holothuria scabra) Extracts using Wet Rendering Extraction Method Nunik Gustini; Diah Anggraini Wulandari; Fauzy Rachman; Eris Septiana; Siti Irma Rahmawati; Gita Syahputra; Martha Sari; Masteria Yunovilsa Putra
Jurnal Kimia Sains dan Aplikasi Vol 26, No 1 (2023): Volume 26 Issue 1 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.1.1-9

Abstract

Antioxidant and anticancer activities of sand sea cucumber Holothuria scabra (dried and fresh) extracts were studied. The highest extraction yield of sea cucumber H. scabra (3.9%) was obtained using dried H. scabra at 60oC. The highest antioxidant activity was found in fresh H. scabra extract at 60°C with an IC50 value of 629.89 ± 0.15 µg/mL using the ABTS method, and the highest antioxidant activity by DPPH method was found in dried H. scabra extract at 70°C with an IC50 value of 32017.18 ± 0.82 µg/mL. The best antioxidant activity based on FRAP and TBARS methods was found in fresh H. scabra extracts at 80°C, respectively. The highest total phenol and flavonoid contained in dried H. scabra extract were 317.54 ± 8.91 mg GAE/100 g sample and 247.56 ± 11.70 mg QE/100 g sample. H. scabra extracts inhibited more than 50% of the growth of the MDA-MB-231 cell line at concentrations of 25 and 50 μg/mL except for dried H. scabra extracts at 80°C. Similarly, the extracts showed the highest cytotoxic effect up to 100% at the highest concentration (100 μg/mL) except for dried H. scabra extracts at 70°C and 80°C.
Co-Authors Diah Anggraini Wulandari Eris Septiana Gita Syahputra Martha Sari Masteria Yunovilsa Putra Nunik Gustini Rahmawati, Siti Irma