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All Journal JURNAL BIOLOGI PAPUA
Aditya K. Karim
Jurusan Biologi FMIPA Universitas Cenderawasih, Jayapura–Papua
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Materials Science & Nanotechnology

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Antiproliferatif Ekstrak Metanol Daun Dianella nemorosa Lam. (Liliaceae) terhadap Sel Kanker MKN45 dengan Menggunakan Metode WST-1 Aditya K. Karim; Sismindari Sismindari
Jurnal Biologi Papua Vol 3, No 2 (2011)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.909 KB) | DOI: 10.31957/jbp.548

Abstract

Dianella nemorosa Lam. was known containing alkaloids, terpenoid, phenolic compouds and tanin. Antiproliferative effect of D. nemorosa leaves methanol exctract, which demonstrated to have an in vitro cytotoxic effect on cancer cell line. The aim of research was examined the effect antiproliferative methanol extract of D. nemorosa leaves against MKN45 (gastric cancer) cell line. Leaves powder extracted using methanol. Antiproliferative effect was determined by Cell Proliferation Reagents WST-1 ((2-(4-iodophenyl)-3-(4-nitro-phenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt). Test for 1h, 2h, and 4h after incubated for 72h was done. The result of this research showed that methanol exctract from D. nemorosa possessed remarkable no had antiproliferative activity against MKN45 cell line. The result indicated methanol extract of D. nemorosa leaves selective inhibitory effect or antiproliferative against cell line. Key words: Dianella nemorosa, Antiproliferative, MKN 45, and WST-1
Peran Herpetofauna dalam Bidang Kesehatan: Peluang dan Tantangan Aditya K. Karim; Zainal A. Wasaraka; Linus Y. Chrystomo; Ervina Indrayani
Jurnal Biologi Papua Vol 4, No 1 (2012)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.439 KB) | DOI: 10.31957/jbp.534

Abstract

Skin secretions and venom from many species of amphibi (frogs and toads) and reptil (group of herpetofauna) from different famillies contain a wide range of unique physiological compounds with biological activity such as peptide, protein, non-protein, and enzyme. They are potent for drug development. The compounds, known as mode of action have practical application as pharmaceutical agents, diagnostic reagents or preparative tools. Peptides with potential anticancer, fibrinolityc, antibacterial, antifungal, antidiabetic activity play important roles in human health. This review introduces roles of herpetofauna for drugs development, potential therapeutic values and their application in human health and disease.Key words: Herpetofauna, skin secretion, venom, drugs development, health.
Co-Authors Ervina Indrayani Linus Y. Chrystomo Sismindari Sismindari Zainal A. Wasaraka