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All Journal Biology, Medicine, & Natural Product Chemistry
Mary Adelaide Oladipo
Ladoke Akintola University of Technology
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Synthesis, Spectroscopic Analysis and Antidiabetic Properties of Copper (II) Complex of Mangifera indica Leaf Crude Extract Mary Adelaide Oladipo; Folasade Omobolanle Ajao; Adewusi John Adepoju; Kayode Taiwo Ishola; Olalekan Jamiu Ajeigbe
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.315-321

Abstract

Many applied conventional drugs in treating diabetes have been reported to possess some drawbacks which necessitate a search for alternative therapies. In order to search for a more active antidiabetic agent, this study synthesized and evaluated antidiabetic properties of Mangifera indica crude extract and its Cu (II) complex in alloxan-induced diabetic albino rats. The leaf crude extract and its metal complex were characterized using percentage metal analysis and IR spectroscopic data. Experimental animals were induced by a single intraperitoneal injection of Alloxan monohydrate at a single dose of 140 mg/kg body weight and animals with fasting blood glucose level (BGL) > 200 mg/dL were considered diabetic. Metformin was used as a standard drug. Fasting blood glucose level and body weight were used to assess the antidiabetic activity. One-way ANOVA was used to determine the level of statistically significant at p< 0.05. The crude extract was found to coordinate with the metal ion through O donor atom of C=O and O-H of phenol and ketone respectively. The Cu (II) complex of the crude extracts at tested dose of 600mg/kg demonstrated more antidiabetic activity without weight gain than the standard drug. It is concluded that the Cu (II) complex could be a potential material in the development of more active and negative-side-effect-free antidiabetic drug.
Analysis of Biological Activities of Two Novel Metal (II) Complexes of Andrographis Paniculata Crude Extract Mary Adelaide Oladipo; Ayodele Oluwabunmi Ojo; Kayode Taiwo Ishola
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.391-397

Abstract

Many diseases in nature have led to the death of many young and old. Many bacteria have developed resistance to the available antibiotics on the market. And many drugs employed in treating many diseases such as diabetes mellitus are expensive and are not locally available. Therefore, in order to search for more effective, inexpensive, and locally available drugs, this study synthesized and investigated the biological activities of Andrographis paniculata crude extract and its Co (II) and Ni (II) complexes. The crude extract and synthesized complexes were characterized using a solubility test, Infrared, and Ultraviolet-Visible spectroscopic analysis. Their antibacterial potentials were investigated against two gram-negative bacteria (Escherichia coli,Staphylococcus aureus) and three gram-negative bacteria (Proteus, Klebsiella, Pseudomonas) while their antidiabetic activities were examined against ?-amylase and ?-glucosidase enzymes. Acarbose was employed as a standard drug. The crude extract and its metal complexes showed different degrees of solubility in the employed solvents. Infrared analysis suggested coordination of the crude extract to the metal ions through the oxygen donor atom while the formation of the complexes was affirmed through the occurrence of d-d transitions in the visible region of the metal complexes. The metal complexes were found to display more antibacterial activity than the crude extract. Co (II) and Ni (II) complexes of the crude extract were found to exhibit better activities against ?-amylase and ?-glucosidase enzymes, respectively than the crude extract and acarbose. It is concluded that the metal complexes could be considered potential antibacterial and antidiabetic agents.
Co-Authors Adewusi John Adepoju Ayodele Oluwabunmi Ojo Folasade Omobolanle Ajao Kayode Taiwo Ishola Kayode Taiwo Ishola Olalekan Jamiu Ajeigbe