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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Radiyati Umi Partan
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Genu Sinistra Tuberculosis Arthritis with Drug-Induced Liver Injury Caused by Anti-Tuberculosis Drugs in Patients Confirmed with COVID-19 Yonis Ismed; Radiyati Umi Partan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.461

Abstract

Background: Tuberculous arthritis is a form of extrapulmonary tuberculosis and has a significant effect on patient morbidity and mortality. This case report aims to describe clinical signs and symptoms, results of laboratory tests, radiology, and outcome of tuberculosis arthritis cases. Case presentation: A 36-year-old woman came to the emergency room with the main complaint of pain, swelling, and warmth when palpating the knee for the past week. The pain felt worse during activities such as walking. The patient also complains of fever, loss of appetite, and unwanted weight loss. Physical examination showed sharp pain and swelling in the knee, limited range of movement (ROM), and a positive balloon sign, while laboratory tests showed increased leukocytes, neutrophils, and C-reactive protein. After the diagnosis of genu tuberculosis arthritis was established, the administration of anti-tuberculosis drugs (OAT) was started. After one week, the patient complained of pain in the left knee and progressive nausea. Liver function tests showed an increase in SGOT and SGPT. The patient then started OAT desensitization. A month later, the patient underwent an open synovectomy with liquefaction necrosis. Although the first desensitization of tuberculosis still causes drug-induced liver injury, the second desensitization involves gradually increasing doses of rifampicin accompanied by close monitoring of liver tests. Conclusion: Early administration of anti-tuberculosis drugs in tuberculosis arthritis can improve healing, maintain joint function, and prevent further damage. Anti-tuberculosis drug desensitization is the primary management of drug-induced liver injury.
Calcipenic Rickets Accompanied by Hypercoagulability, Hypokalemia and a History of Secondary Amenorrhea: A Case Report Radiyati Umi Partan; Merylla Filianty Sipayung; Ratna Maila Dewi
Archives of The Medicine and Case Reports Vol. 4 No. 2 (2023): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v4i2.290

Abstract

mineralization. This case report aims to present a patient with calcipenic rickets, which are accompanied by hypercoagulability, hypokalemia, and secondary amenorrhea. In this case, a woman, 21 years old, unmarried, living outside the city of Palembang, came to the endocrine polyclinic with complaints of leg pain, making it difficult to walk along with growth retardation. In addition, there is a lump on the right arm and left knee that does not enlarge, height and weight do not increase, and both legs are bent. Based on physical examination, the general condition looked moderately ill, with vital signs within normal limits, body weight 26 kg, height 123 cm, and body mass index 17.8 kg/cm2. In the superior extremity, a 2-3 cm mass was found in the right humerus. In the lower extremities, there was a mass measuring 3 cm in the left lateral genu, supple and easy to move, with no pain. On examination of genital maturity, Tanner 2 was found. Laboratory evaluation results at the first visit to the endocrine clinic showed increased fibrinogen, d-dimer level, parathyroid hormone, and alkaline phosphatase. In addition, there was a decrease in calcium, potassium, vitamin D-25 OH, phosphorus, growth hormone, and anti-Mullerian hormone. Bone age examination shows bone age according to girls aged 15 years. The patient was diagnosed with calcigenic type rickets with hypercoagulability, hypokalemia, and secondary amenorrhea. Initial management is given calcium 500-4000 g/day, potassium 40-100 mEq/24 hours, warfarin 2 mg/24 hours, acetylsalicylic acid 80 mg/24 hours, vitamin D 1000 mg/24 hours, CaCO3 500 mg/8 hours, potassium chloride 600 mg/12 hours. In conclusion, cases of rickets are quite rare and require further examination to establish a diagnosis.
Genu Sinistra Tuberculosis Arthritis with Drug-Induced Liver Injury Caused by Anti-Tuberculosis Drugs in Patients Confirmed with COVID-19 Yonis Ismed; Radiyati Umi Partan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.461

Abstract

Background: Tuberculous arthritis is a form of extrapulmonary tuberculosis and has a significant effect on patient morbidity and mortality. This case report aims to describe clinical signs and symptoms, results of laboratory tests, radiology, and outcome of tuberculosis arthritis cases. Case presentation: A 36-year-old woman came to the emergency room with the main complaint of pain, swelling, and warmth when palpating the knee for the past week. The pain felt worse during activities such as walking. The patient also complains of fever, loss of appetite, and unwanted weight loss. Physical examination showed sharp pain and swelling in the knee, limited range of movement (ROM), and a positive balloon sign, while laboratory tests showed increased leukocytes, neutrophils, and C-reactive protein. After the diagnosis of genu tuberculosis arthritis was established, the administration of anti-tuberculosis drugs (OAT) was started. After one week, the patient complained of pain in the left knee and progressive nausea. Liver function tests showed an increase in SGOT and SGPT. The patient then started OAT desensitization. A month later, the patient underwent an open synovectomy with liquefaction necrosis. Although the first desensitization of tuberculosis still causes drug-induced liver injury, the second desensitization involves gradually increasing doses of rifampicin accompanied by close monitoring of liver tests. Conclusion: Early administration of anti-tuberculosis drugs in tuberculosis arthritis can improve healing, maintain joint function, and prevent further damage. Anti-tuberculosis drug desensitization is the primary management of drug-induced liver injury.
Co-Authors Merylla Filianty Sipayung Ratna Maila Dewi Yonis Ismed