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All Journal Acta Biochimica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA
Fadilah Fadilah
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering

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Spirulina platensis effect on oxidative stress of rat’s offspring brain exposed to cigarette smoke during pregnancy and lactation Kenny Cantika Abadi; Febriana Catur Iswanti; Sri Widia A Jusman; Fadilah Fadilah; Ani Retno Prijanti
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.64

Abstract

Background: Maternal exposure to cigarette smoke during pregnancy and lactation might harmful for the fetus. The smoke contains many free radicals that could be eliminated by antioxidant. This study aimed to investigate the effect of Spirulina platensis ethanol extract as antioxidant against cigarette smoke exposure during pregnancy until lactation by assessing oxidative stress markers in neonatal brain tissues. Methods: The experimental study used 26 offspring divided into four groups: (C) = offspring of maternal control group; (Cg) = offspring of maternal exposed to cigarette smoke; (CgSp) = offspring of maternal given spirulina and exposed to cigarette smoke; and (Sp) = offspring of maternal given spirulina only group, during gestation and 9 days lactation (30 days). Each group consisted of 6 offspring obtained from 2 adult females mated with male Sprague-Dawley rats. The exposure of cigarette smoke was 4 burn cigarettes/day for 30 days. The dose of extract was 200 mg/kg BW. The offspring were sacrificed, and the brain tissues were taken for MDA, MnSOD activity, as well as catalase activity, carbonyl, and GSH. Results: There was no significant differences in MDA level between groups. The carbonyl, SOD, and catalase activity did not differ between the control and smoked group. Conclusion: Exposure of four burned cigarettes smoke per day during pregnancy, and 9 days of lactation did not trigger oxidative stress. However, the effect of Spirulina platensis administration on rat offspring brain could not be analyzed.
The Evolution of Zoonosis-Related Studies in Indonesia, 1977-2023: Bibliometric Analysis Concepts Diana Nurjanah; Indi Dharmayanti; Fadilah Fadilah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/465

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Various zoonotic diseases have been reported as epidemics throughout the world, including in Indonesia. Various studies have been conducted related to gaps in knowledge, especially on disease distribution, etiology, pathogens, hosts, vector biology, dynamics, cycle of transmission, predisposing factors, and risk factors. To find out the dynamics of zoonotic disease study and research in Indonesia, a study was conducted to report a literature analysis that focused on bibliometric analysis of the Scopus database and VOSviewer software to create a visualization map that identified how the evolution of zoonotic diseases studies from 1977-2023 in Indonesia. In co-occurrence analysis, two units of analysis are used, namely "author keywords" and "index keywords" in VOSviewer. It showed that studies related to zoonoses in Indonesia tend to increase every year with a significant increase in 2020 and 2022. Document types are dominated by articles (72%) with subjects or research areas related to “medicine” (29%). From the "author keywords" analysis unit, the words "zoonosis" and "Indonesia" were the words that appeared the most. Meanwhile, from “index keywords” six clusters were found with the word "human" "animals", and "zoonosis" being the word that appears the most in the analysis of the studies conducted.
Co-Authors Ani Retno Prijanti Diana Nurjanah Febriana Catur Iswanti Indi Dharmayanti Kenny Cantika Abadi Sri Widia A Jusman