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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) INFOKUM
Fauna Herawati
University of Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Materials Science & Nanotechnology Physics

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BENEFITS AND SAFETY OF INSULIN THERAPY IN PEDIATRIC AND ADOLESCENT PATIENTS SUFFERING FROM CYSTIC FIBROSIS-RELATED DIABETES MELLITUS (CFRD): A SYSTEMATIC REVIEW I Gusti Agung Nyoman Indira Prana; Fauna Herawati
INFOKUM Vol. 10 No. 5 (2022): December, Computer and Communication
Publisher : Sean Institute

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Abstract

About 40% of conditions of glucose intolerance occur in children aged 6-10 to adolescents with cystic fibrosis who are deficient in insulin. Hyperglycemia can occur before a person with cystic fibrosis is diagnosed with CFRD, with a significant reduction in clinical patients in glucose intolerance and an increased risk of lung organ failure. This systematic study aimed to determine the benefits and safety of providing insulin therapy in children and adolescents with Cystic Fibrosis-related Diabetes Mellitus (CFRD). The process of searching published literature through online databases such as Pubmed, Cochrane Library, ScienceDirect, and Google Scholar using the keywords Children, Insulin, Cystic Fibrosis, and Diabetes Mellitus using the Boolean operator "AND". A total of eight studies were selected with criteria not limited to just the type of RCT, patients with an age range of 1 month -18 years were diagnosed with Cystic Fibrosis-related Diabetes Mellitus (CFRD), and compared with insulin therapy with placebo, other OAD, or no therapy. From the eight kinds of literature that were reviewed systematically, it was shown that the administration of insulin therapy had benefits in improving the clinical status of the patient, such as decreasing the% HbA1c value, increasing FEV1, and improving the patient's nutritional status through the patient's BMI parameter, besides that insulin therapy was considered safe and tolerable by children and adolescents suffering from Cystic Fibrosis-related Diabetes Mellitus.
Effectiveness of Stalevo Drug Usage in Parkinson's Patients: A Narrative Review M Andri Prasetyo; Fauna Herawati
Jurnal Penelitian Pendidikan IPA Vol 12 No 3 (2026): In Progress
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i3.14651

Abstract

Parkinson's Disease (PD) is a neurodegenerative disorder that affects patients' quality of life, with primary motor symptoms such as tremor, muscle rigidity, and bradykinesia. Levodopa is the mainstay of PD therapy, but approximately 80% of patients experience motor complications, such as motor fluctuations and "wearing-off" after several years of therapy. This study evaluates the efficacy, safety, and rational use of Stalevo (levodopa, carbidopa, and entacapone) in managing motor complications and "wearing-off" phenomena in patients with Parkinson's Disease (PD). This research was conducted as a narrative review to provide a recent evidence-based synthesis of the efficacy and safety of Stalevo. Methods included a search of articles in PubMed, ScienceDirect, and Google Scholar published between 2015 and 2025 using the keywords "Stalevo" and "Parkinson's disease." The study revealed that Stalevo was effective in prolonging the duration of levodopa's effect, reducing the required levodopa dose, and improving patients' quality of life, particularly in patients with motor fluctuations. Although side effects such as dyskinesia and diarrhea may occur, Stalevo's overall safety profile is well-received. Stalevo is a cost-effective, evidence-based intervention for intermediate-to-advanced PD. Rational use requires precise patient selection and monitoring for dopaminergic side effects, such as dyskinesia and diarrhea, to optimize quality of life and ensure patient safety.
Co-Authors I Gusti Agung Nyoman Indira Prana M Andri Prasetyo