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All Journal e-CliniC Medical Scope Journal (MSJ)
Ferdinand Tjandra
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Radiotherapy Role in Rectal Cancer at Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia Jeffri Jeffri; Ferdinand Tjandra; Michael Tendean; Toar Mambu; Enrico Napitupulu
Medical Scope Journal Vol. 4 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v4i2.47630

Abstract

Abstract: Rectal cancer (RC) remains as a major health burden, being the 3rd most common form of cancer and leading cause of death. RC effects as much as 12.8 per 100 adult population with a mortality rate as high as 9.5%.1 Efforts were made to reduce morbidity and mortality due to rectal cancer. One of them is radiotherapy acting as both neoadjuvant and adjuvant. Thus study aimed to emphasize the role of radioteraphy in treating rectal cancer patients at Prof. Dr. R. D. Kandou General Hospital, Manado. This was a retrospective study using data of all rectal cancer outpatients seeking at Prof. Dr. R. D. Kandou General Hospital, Manado. from 2017-2020 especially of those receiving radiotherapy treatment in radiology department. The results obtained a total 119 patients, 28 of them received radiotherapy based on staging and clinical judgement. From the radiotherapy group, 46.4% patient received neoadjuvant radiotherapy primary to surgical procedure, and among the neoadjuvant group 71.4% received long course radiotherapy. From the neoadjuvant radiotherapy group, 46.4% became resectable and 46.4% among them underwent Miles Procedure. In conclusion, rectal cancer is still a health problem, and radiotherapy as one of the modality play major role as neoadjuvant and adjuvant treatment.
Therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP): A Single Centre 5-Year Experience Michael Tendean; Toar D. B. Mambu; Ferdinand Tjandra; Billy Salem; Jimmy Panelewen; Everly Corputty
e-CliniC Vol. 11 No. 3 (2023): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v11i3.46027

Abstract

Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) and related procedures are established as necessary techniques in the diagnosis and treatment of biliopancreatic diseases. Caution is needed due to the high risk of complications that can be fatal. The main complications are pancreatitis, bleeding, perforation, biliary stents, and lithiasis treatment issues. This study aimed to evaluate the therapeutic ERCP at Prof. Dr. R. D. Kandou Hospital between 2017-2021. This was a retrospective study using patients’ medical record data. The results obtained a total of 196 ERCP procedures performed at Prof. Dr. R. D. Kandou Hospital in that period. Variations of etiology, technical difficulties, and morbidities were recorded. The success rate of endoscopic stone extraction was 77.9 %, EPBD 10.71 %, and stenting for biliary drainage 97.3 %. Etiology varied from bile duct stone (74%); malignancies of the pancreas (8%), duodenum (2%), and periampullary (4%); Klatskin tumor (5.6%); and other malignancies (5%). Associated morbidities were melena 2%, pancreatitis 1%, and cholangitis 0.5%. In conclusion, endoscopic retrograde cholangiopancreatography is a reliable method for the diagnosis and treatment of hepatobiliary and pancreatic diseases, shown by the low incidence of morbidities and mortalities. Keywords: endoscopic retrograde cholangiopancreatography; biliopancreatic diseases
Hubungan antara Tumor-Infiltrating Lymphocytes dengan Stadium dan Derajat Diferensiasi Adenokarsinoma Kolorektal Karina E. Clearesta; Toar Mambu; Ferdinand Tjandra; Fredrik G. Langi
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.48480

Abstract

Abstract: Colorectal cancer has high incidence and mortality rates. Tumor-infiltrating lymphocytes (TILs) are histopathological findings that depict the individual's immune response to the tumor. This study aimed to investigate the relationship between TILs and the differentiation grade and stage of colorectal adenocarcinoma. This was an analytical and observational study with a cross-sectional design. The results showed 34 patients with colorectal adenocarcinoma who met the criteria. The sample characteristics consisted of male (64.7%), mean age (59.15 ± 10.78), tumor location in the colon (43.9%) and rectum (55.8%), average TILs (25.62 ± 17.39), moderate TILs grade (50%), stage III tumor (50%), and moderately differentiated tumors (70.6%). A significant association was found between TILs and tumor differentiation grade (p=0.024). Post hoc analysis showed a significant difference in TILs between good and poor differentiation (p=0.04; 95% CI: 1.52-64.48). A cut-off value for TILs was identified for good differentiation (TIL>27) and moderate/poor differentiation (TIL≤27) with a sensitivity of 69.2% and specificity of 75.0%. The extent of lymphocytic invasion of tumor tissue reflected the host's immune status. TILs played an important role in tumor development and was a good prognostic factor in colorectal cancer. In conclusion, TILs can be used as a predictor for the differentiation grade of colorectal adenocarcinoma. Keywords: colorectal adenocarcinoma; tumor infiltrating lymphocytes; differentiation grade   Abstrak: Kanker kolorektal memiliki angka kejadian dan mortalitas tinggi. Tumor-infiltrating lymphocytes (TILs) merupakan temuan histopatologik yang menggambarkan respon imunologis individu terhadap tumor. Penelitian ini bertujuan untuk mengetahui hubungan antara TILs dengan derajat diferensiasi dan stadium pada adenokarsinoma kolorektal. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Hasil penelitian mendapatkan 34 pasien dengan adenokarsinoma kolorektal yang memenuhi kriteria. Karakteristik sampel terbanyak ialah jenis kelamin laki-laki (64,7%), rerata usia (59,15 ± 10,78), lokasi tumor di kolon (43,9%) dan rektum (55,8%), rerata TILs (25,62 ± 17,39), derajat TILs moderate (50%), stadium tumor derajat III (50%) dan derajat diferensiasi tumor sedang (70,6%). Terdapat hubungan bermakna TILs dengan derajat diferensiasi tumor (p=0,024). Analisis post hoc bermakna terhadap derajat TILs baik vs buruk (p=0,04; 95% CI: 1.52-64.48). Nilai cut-off TILs dengan derajat diferensiasi baik (TIL>27) dan sedang/buruk (TIL≤27) dengan sensitivitas 69,2% dan spesifisitas 75,0%. Luasnya invasi limfositik pada jaringan tumor mencerminkan status kekebalan tubuh pejamu. TILs berperan penting dalam perkembangan tumor dan merupakan faktor prognostik yang baik pada kanker kolorektal. Simpulan penelitian ini ialah nilai TILs dapat digunakan sebagai faktor prediktor derajat diferensiasi adenokarsinoma kolorektal. Kata kunci: adenokarsinoma kolorektal; tumor infliltrating lymphocytes; derajat diferensiasi
Co-Authors Billy Salem Enrico Napitupulu Everly Corputty Fredrik G. Langi Jeffri Jeffri Jimmy Panelewen Karina E. Clearesta Michael Tendean Toar D. B. Mambu Toar Mambu