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All Journal Jurnal Gizi Klinik Indonesia Indonesian Journal of Perinatology
Setya Wandita, Setya
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Newer technique in surfactant administration Wandita, Setya
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.41

Abstract

Respiratory distress syndrome (RDS) is a morbidity often found in premature infants. The incidence of RDS is inversely proportional to gestational age and decreases with the presence of antenatal steroids. Surfactant is a phospholipid produced by type 2 pneumatocytes. Surfactant coats the alveoli and bronchioles so that their surface tension is reduced. Thus, the alveoli and bronchioli remain open, allowing gas exchange. After surfactants are known to benefit RDS, the next question is when is the right time to give them. There are 2 alternative times for surfactant therapy, namely before symptoms appear or a diagnosis is made (prophylaxis) and after RDS symptoms appear (rescue). Several Newer techniques in surfactant administration will be discussed in this article.
Maternal and perinatal factors affecting vitamin D status of very low birth weight infants hospitalized in neonatal intensive care unit Wibowo, Tunjung; Anggraini, Alifah; Safrida, Elysa Nur; Wandita, Setya; Haksari, Ekawaty Lutfia
Jurnal Gizi Klinik Indonesia Vol 20, No 3 (2024): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.91172

Abstract

Background: Vitamin D deficiency is a global problem in premature infants. Vitamin D deficiency is associated with skeletal and non-skeletal disease. In premature infants, vitamin D deficiency is primarily associated with metabolic bone disease. Objective: The study aims to investigate the prevalence and risk factors of vitamin D deficiency in very low birth weight (VLBW) infants who were hospitalized in the neonatal intensive care unit (NICU) of a tertiary hospital in a developing country. Methods: A retrospective cohort was conducted at the NICU of Dr. Sardjito General Hospital, Yogyakarta. VLBW infants (inborn and outborn), hospitalized between January 1, 2018, and December 31, 2020, were enrolled in this study. Data on maternal (age (years), parity, education level, and socio-economic status) and neonatal (birth weight, birth length, and head circumference), gestational age, age of serum 25 hydroxy-vitamin D (25-OHD), sex, type of feeding, postnatal steroid) was taken from the medical records. Serum 25-OHD measurement was conducted at the age of around 4 weeks. Throughout the first 24 hours following birth, all infants at Dr. Sardjito General Hospital weighing <1,500g would receive total parenteral nutrition (TPN). For infants who were referred to Sardjito General Hospital, nutritional and feeding history including TPN was assessed through anamnesis from the nurses or midwives who transport the patient and from referral records. Results: A total of 165 very low birth weight infants consisting of 88 male and 77 female newborns were included in this study. The mean ± SD of the vitamin D level was 11.5 ± 7.6 ng/ml (range 2.9 - 45.5 ng/ml). The prevalence of Vitamin D insufficiency, deficiency, and severe deficiency were 12.1; 55.2; and 23%; respectively. Receiving TPN was positively and independently associated with vitamin D levels (p=0.006). Conclusions: There is a positive relationship between the administration of TPN and serum 25-OHD level in VLBW infants hospitalized in the NICU.
Co-Authors Alifah Anggraini, Alifah Bawono, Kornelius Dandung Ekawaty Lutfia Haksari, Ekawaty Lutfia Elisabeth Siti Herini Safrida, Elysa Nur Tunjung Wibowo