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All Journal Indonesian Journal of Chemistry
Ali Jabbar Jasim Makkawi
Department of Chemistry, College of Science, University of Babylon, Ministry of Education, Hilla 51002, Iraq
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells Fattima Al-Zahra Gabar Gassim; Ali Jabbar Jasim Makkawi
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76872

Abstract

In this work, a refluxing method is used to prepare nanoparticles of zinc oxide (ZnO NPS) and zinc oxide /silver chloride nanocomposites (ZnO/AgCl NCS). The structural properties of nanocrystals are studied by Atomic Force Microscope (AFM), X-Ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM) to determine the average crystal size, morphology, particle size and average grain size of nanocrystals. The results of anticancer efficiency of ZnO NPs and ZnO/AgCl NCs show cytotoxic activity against five human cancer cells, namely hepatocellular carcinoma, rhabdomyosarcoma (RD), colorectal carcinoma (HCT116), mammary gland (MCF-7), and epidermoid carcinoma (Hep2) compared against doxorubicin. The anticancer mechanism of pure and nanocomposites ZnO are suggested according to the release of Zn+2 and the production of reactive oxidation species (ROS) and the effect of these species on cancer inhibition.
Co-Authors Fattima Al-Zahra Gabar Gassim