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All Journal Indonesian Journal of Chemistry
Dina Kartika Maharani
Department of Chemistry, Faculty of Science and Mathematics, Universitas Negeri Surabaya, Jl. Ketintang, Surabaya 60231, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Characterization and Antibacterial Activity Assessment of Hydroxyapatite-Betel Leaf Extract Formulation against Streptococcus mutans In Vitro and In Vivo Fitriari Izzatunnisa Muhaimin; Sari Edi Cahyaningrum; Riska Amelia Lawarti; Dina Kartika Maharani
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.77853

Abstract

Hydroxyapatite is an inorganic material that is commonly used as a re-mineralizing agent. Adding natural ingredients such as green betel leaf can increase the antibacterial properties due to the presence of phenolic compounds, flavonoids, and tannins. This study aims to determine the physical and chemical characteristics of the formulation of hydroxyapatite-betel leaf extract and the antibacterial activity against Streptococcus mutans. To characterize the combination of hydroxyapatite-betel leaf extract, XRD, PSA and FTIR analyses were performed. Particle size analysis showed the smallest results in the variation of betel 0.3 g, which is 690.08 nm. FTIR characterization showed the presence of OH, PO43− and CO32− functional groups from hydroxyapatite and C=O derived from betel leaf extract. In addition, in vitro and in vivo analyses were performed to assess the antibacterial activity of this formulation. The in vitro antibacterial activity test against S. mutans showed strong inhibitory activity. Our finding suggests that the formulation has the potential to be used as a medication or prevention agent for dental caries.
Co-Authors Fitriari Izzatunnisa Muhaimin Riska Amelia Lawarti Sari Edi Cahyaningrum