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All Journal Jurnal Widya Medika
Sayu Widiawati
Sanjiwani Regional General Hospital, Gianyar
Medicine & Pharmacology

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CORRELATION OF SERUM ZINC LEVELS WITH SEVERITY AND DISEASE ACTIVITY IN VITILIGO PATIENTS AT SANJIWANI GIANYAR HOSPITAL Sayu Widiawati; Made Budiani; Pradnya Iswara
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4230

Abstract

Vitiligo is autoimmune disease, characterized by well defined milky-white macule, caused by destruction of melanocyte selectively. Management of vitiligo is still challenging due to the pathogenesis is not yet fully understood, and vitiligo can caused significant psychological distress to the patients. Several studies reveal the role of zinc as an important element in the prevention and treatment of vitiligo based on zinc's function as an antiapoptotic, as a bull against free radicals, and as an important element in melanogenesis by stimulating cell mediated immunity activity, zinc and alpha melanocyte stimulating hormone. We conducted an analytical cross-sectional study that aims to determine the correlation between plasma zinc levels and the severity of vitiligo using the VASI score and vitiligo disease activity calculated based on the VIDA score. The results showed that there was a strong negative correlation between serum zinc levels and the VASI score, with a correlation coefficient or r = -0.668 and p
Co-Authors Made Budiani Pradnya Iswara