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All Journal Jurnal Ners Indonesian Journal of Global Health Research
Aldila Ayu Widya
Universitas Nahdlatul Ulama Surabaya
Health Professions Medicine & Pharmacology Nursing

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The Relationship Between Chronic Kidney Disease and Sarcopenia: A Systematic Review Eppy Setyowati; Ragil Putri Fitriyanti; Aldila Ayu Widya; Justinho Soares
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1246

Abstract

Chronic kidney disease (CKD) is a growing global health problem and is associated with multiple systemic complications. One important but often underrecognized complication is sarcopenia, characterized by progressive loss of muscle mass, strength, and physical performance. Sarcopenia is highly prevalent in patients with advanced CKD and those undergoing hemodialysis and is associated with poor clinical outcomes, including increased hospitalization, functional decline, and mortality. This literature review aimed to synthesize recent evidence on the relationship between CKD and sarcopenia, including prevalence, contributing factors, pathophysiological mechanisms, and clinical implications. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searches were conducted in PubMed, ScienceDirect, Google Scholar, and Semantic Scholar for English-language articles published between 2020 and 2025. Study selection was guided by the PICOS framework. Methodological quality was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. A total of 15 studies meeting the inclusion criteria were included in the final synthesis. The included studies reported a high prevalence of sarcopenia among CKD patients, ranging from 15.9% to 64.1%, with higher rates observed in advanced CKD stages and hemodialysis populations. Sarcopenia was consistently associated with older age, malnutrition, protein–energy wasting, chronic inflammation, reduced physical activity, and metabolic disturbances. Clinically, sarcopenia was linked to increased mortality, hospitalization, reduced physical function, and poorer quality of life. Sarcopenia is a prevalent and clinically significant complication of CKD. Early detection and integrated interventions combining nutritional optimization, resistance exercise, and metabolic management are essential to improve patient outcomes. Further longitudinal studies are needed to strengthen preventive and therapeutic strategies.
Hubungan Dukungan Keluarga dengan Kepatuhan Diet dan Obat Pasien Diabetes Mellitus Tipe 2 di Puskesmas X Eppy Setiyowati; Aldila Ayu widya; Feby Ayu Miladiya; Intan Cahyanti Sugianto
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.60223

Abstract

Diabetes mellitus tipe 2 merupakan penyakit kronis yang memerlukan manajemen jangka panjang melalui kepatuhan diet dan pengobatan. Dukungan keluarga menjadi salah satu faktor eksternal yang berperan penting dalam meningkatkan kepatuhan pasien. Penelitian ini bertujuan untuk menganalisis hubungan antara dukungan keluarga dengan kepatuhan diet dan kepatuhan minum obat pasien diabetes mellitus tipe 2 di Puskesmas X. Penelitian ini menggunakan desain korelasional dengan pendekatan cross-sectional. Sampel penelitian sebanyak 68 responden yang diambil dengan teknik purposive sampling. Instrumen penelitian menggunakan kuesioner dukungan keluarga dan kuesioner kepatuhan diet serta kepatuhan minum obat. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara dukungan keluarga dengan kepatuhan diet (p = 0,002; r = 0,365) dan dukungan keluarga dengan kepatuhan minum obat (p = 0,000; r = 0,456). Semakin tinggi dukungan keluarga yang diberikan, semakin tinggi pula kepatuhan pasien dalam menjalani diet dan minum obat. Penelitian ini merekomendasikan peran aktif keluarga dalam program manajemen diabetes mellitus.
Co-Authors Eppy Setiyowati Eppy Setyowati Feby Ayu Miladiya Intan Cahyanti Sugianto Justinho Soares Ragil Putri Fitriyanti