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All Journal Journal Of World Science Diagnosa: Jurnal Ilmu Kesehatan dan Keperawatan
Raja Iqbal Mulya Harahap
Universitas Padjadjaran
Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences

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PERBANDINGAN BIAYA PEMERIKSAAN LABORATORIUM PADA PASIEN TUBERKULOSIS MULTIDRUG RESISTANCE (TB-MDR) DENGAN TUBERKULOSIS EXTENSIVE DRUG RESISTANCE (TB-XDR): STUDI PADA RUMAH SAKIT TERSIER DI BANDUNG Raja Iqbal Mulya Harahap; Juandika Juandika; Dety Mulyanti
DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan Vol. 1 No. 1 (2023): Februari : Jurnal Ilmu Kesehatan dan Keperawatan
Publisher : Universitas Katolik Widya Karya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (977.474 KB) | DOI: 10.59581/diagnosa-widyakarya.v1i1.156

Abstract

Introduction. Tuberculosis (TB) is one of the oldest diseases known to attack humans, caused by the bacterium Mycobacterium tuberculosis. Multi-drug-resistant TB (MDR-TB) is a stage or condition in which Mycobacterium tuberculosis becomes minimally resistant to rifampicin administration and also insonicotinylhydrazine (INH). Extensive-drug-resistant TB (XDR-TB) is an MDR-TB with Mycobacterium tuberculosis immune characteristics against one of the fluoroquinolone class drugs and one of the second-line injection OAT (capreomycin, kanamycin, and amikacin). The aim of this study was to find out the description of variation in laboratory costs of MDR-TB/XDR patients on one treatment cycle. Method. The inclusion criteria were patients who had been diagnosed with MDR-TB/XDR and performed laboratory tests. The design of this study was a cross-sectional retrospective analytics using medical records of MDR-TB/XDR patients in MDR division. Results. There were 30 MDR-TB research subjects and 2 XDR-TB research subjects examined for laboratory examination. Comparison of laboratory mean of MDR-TB/XDR (p = 0,018). Discussion. There was a significant difference in the total cost of MDR-TB/XDR laboratory examinations in one treatment cycle. Conclusion. Laboratory examination of MDR-TB/XDR patients requires considerable cost, this is due to the side effects of OAT that require patient clinical monitoring.
Laboratory Examination in Congenital Adrenal Hyperplasia: A Literature Review Raja Iqbal Mulya Harahap; Tiene Rostini; Nida Suraya; Srawana Ayu Renaningtyas
Journal of World Science Vol. 5 No. 2 (2026): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v5i2.1628

Abstract

Congenital adrenal hyperplasia (CAH) is a group of inherited genetic disorders that affect the adrenal glands, which produce essential hormones such as cortisol, aldosterone, and sex steroids. The most common form of CAH is caused by a 21-hydroxylase enzyme deficiency resulting from mutations in the CYP21A2 gene. This deficiency disrupts normal cortisol and aldosterone production, leading to excessive androgen synthesis and a range of clinical manifestations, including ambiguous genitalia in females and adrenal crisis in both sexes. Current biomarkers, such as 17-hydroxyprogesterone (17-OHP), androstenedione, and testosterone, have limitations, and further research on 11-oxygenated androgens—which are more specific for CAH—is needed. Non-invasive methods, such as measuring steroids in saliva and urine, are increasingly accessible and useful, particularly for children showing signs of hyperandrogenism.
Co-Authors Dety Mulyanti Juandika Juandika Nida Suraya Srawana Ayu Renaningtyas Tiene Rostini