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Dominus Mbunga
Poltekkes Kemenkes Kupang
Agriculture, Biological Sciences & Forestry Chemistry

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ANTI-INFLAMMATORY ACTIVITIES OF AQUEOUS EXTRACT OF BERINGIN (FICUS BENJAMINA L.) AND KERSEN (MUNTINGIA CALABURA L.) LEAVES IN ALBINO RATS Dominus Mbunga
JURNAL KATALISATOR Vol. 6 No. 2 (2021): Jurnal Katalisator, Volume 6, No 2, 2021
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.346 KB) | DOI: 10.22216/katalisator.v6i2.582

Abstract

Inflammation can increase the risk of various diseases. Currently, many drugs to treat inflammation have serious side effects. Ficus benjamina L. and Muntingia calabura L. have the potential to be safer and more efficient anti-inflammatory agents. Many pharmacological studies of the leaves of these plants have been carried out, but mostly did not use water extract even though traditionally the leaves were taken as infusion or decoction. This research aimed to prove the anti-inflammatory activities of aqueous extract of Ficus Benjamina L. and Muntingia Calabura L. leaves scientifically. Extraction was conducted by the Dekok method. Anti-inflammatory activities were performed based on the inhibition of edema on the paw of the rats, induced by carrageenan lambda 1 % intraplantarely. Results showed that all of the doses of the aqueous extract of Ficus benjamina L. and Muntingia calabura L. leaves had anti-inflammatory activities compared to the negative control (p<0.05). The highest anti-inflammatory activity on the aqueous extract of Ficus benjamina L. leaves was shown at the dose of 264 mg/kg bw with the edema volume percentage 39.71% compared to negative control group 70.12% and percentage of inflammation inhibition was 44.36%. On the aqueous extract of Muntingia calabura L. leaves, the highest anti-inflammatory activity was shown at the dose of 1284 mg/kg bw with the edema volume percentage 38.90%, and the percentage of inflammation inhibition was 46.83%.
AKTIVITAS ANALGETIK DAN ANTI-INFLAMASI EKSTRAK ETANOL DAUN FALOAK (STERCULIA QUADRIFIDA R.Br) Dominus Mbunga; Stefany Fernandez
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.043 KB) | DOI: 10.62769/katalisator.v8i1.2110

Abstract

Penggunaan obat-obatan analgetik opioid, AINS dan atau kortikosteroid untuk meredakan nyeri maupun inflamasi memiliki resiko efek samping yang cukup besar, sehingga mendorong penggunaan obat tradisional di masyarakat. Salah satu tanaman yang digunakan di provinsi NTT adalah tanaman faloak (Sterculia quadrifida R.Br). Selama ini masyarakat hanya menggunakan kulit batang faloak sebagai obat tradisional yang tentu saja bersifat destruktif terhadap tanaman tersebut, padahal daun tanaman faloak memiliki kandungan senyawa yang mirip dengan kandungan kulit batangnya. Penelitian ini bertujuan untuk membuktikan secara ilmiah khasiat daun faloak sebagai analgetik dan anti-inflamasi. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol. Ekstrak daun faloak dosis 100, 200 dan 400 mg/kg bb diuji aktivitas analgetik peripheral dengan metode siegmund, dan analgetik sentralnya dengan metode tail immersion. Ekstrak juga diuji aktivitas anti-inflamasinya menggunakan metode induksi karagenan pada telapak kaki mencit. Hasil penelitian menunjukan bahwa ekstrak daun faloak dosis 400 mg/kg bb memberikan aktivitas farmakologi terbesar baik sebagai analgetik maupun anti-inflamasi yang dibandingkan terhadap kelompok control negatif (p<0.05). Khusus untuk metode siegmund dan induksi karagenan, aktivitas ekstrak dosis 400 mg/kg bb menyerupai control positif (p>0.05). Semua kelompok dosis ekstrak daun faloak memiliki aktivitas analgetic dan anti-inflamasi sehingga diharapkan dapat dijadikan alternative dalam pengobatan.
Co-Authors Stefany Fernandez